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Primary non-Hodgkin's lymphoma of the vagina case report and review of the literature

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Abstract

The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, University of Essen, Hufelandstrasse 55, D-45122, Essen, Germany

    H. -G. Höffkes, A. Schumann, M. Uppenkamp, C. Teschendorf & G. Brittinger

  2. Department of Gynecology, University of Essen, Essen, Germany

    A. E. Schindler

  3. Institute of Hematopathology, University of Kiel, Kiel, Germany

    R. Parwaresch

Authors
  1. H. -G. Höffkes
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  2. A. Schumann
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  3. M. Uppenkamp
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  4. C. Teschendorf
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  5. G. Brittinger
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  6. A. E. Schindler
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  7. R. Parwaresch
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Höffkes, H.G., Schumann, A., Uppenkamp, M. et al. Primary non-Hodgkin's lymphoma of the vagina case report and review of the literature. Ann Hematol 70, 273–276 (1995). https://doi.org/10.1007/BF01784047

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  • DOI: https://doi.org/10.1007/BF01784047

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