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Comparative intraperitoneal pharmacokinetics of three platinum analogues

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  • Platinum Analogues, Pharmacokinetics
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Summary

The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer of fallopian tube carcinoma by following the disposition of tracer doses of195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.

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Authors and Affiliations

  1. CRC Department of Medical Oncology, Christie Hospital and Holt radium Institute, Wilmslow Road, M20 9BX, Manchester, UK

    M. J. Lind, D. J. Murphy & D. Crowther

  2. Department of Medical Biophysics, University of Manchester, Medical School, M20 9BX, Manchester, UK

    H. Sharma, N. Tinker & A. Smith

  3. Department of Chemistry, University of Manchester Institute of Science and Technology, Manchester, UK

    C. A. McAuliffe

Authors
  1. M. J. Lind
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  2. D. J. Murphy
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  3. H. Sharma
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  4. N. Tinker
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  5. A. Smith
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  6. C. A. McAuliffe
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  7. D. Crowther
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Lind, M.J., Murphy, D.J., Sharma, H. et al. Comparative intraperitoneal pharmacokinetics of three platinum analogues. Cancer Chemother. Pharmacol. 28, 315–317 (1991). https://doi.org/10.1007/BF00685543

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  • DOI: https://doi.org/10.1007/BF00685543

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