Summary
Intravenous metoclopramide and IM prochlorperazine and diazepam were compared in the management of vomiting occurring during treatment with cis-dichlorodiammineplatinum (cis-platinum). A total of 104 cycles in 30 patients were evaluated.
Twenty-two patients took part in a cross-over study in which emetic profiles for each patient, managed with each anti-emetic schedule were compared.
In all, 44 cycles of treatment in 22 patients were evaluated as part of a cross-over study. No significant difference in emetic control was observed between the two anti-emetic, regimens.
The side-effects observed using IV metoclopramide included extrapyramidal phenomena (19%) and flushing attacks (16%).
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Luesley, D.M., Terry, P.B. & Chan, K.K. High-dose intravenous metoclopramide and intermittent intramuscular prochlorperazine and diazepam in the management of emesis induced by cis-dichlorodiammineplatinum. Cancer Chemother. Pharmacol. 14, 250–252 (1985). https://doi.org/10.1007/BF00258127
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DOI: https://doi.org/10.1007/BF00258127