Summary
Forty-four adult patients under 60 years of age with acute nonlymphoblastic leukemia were randomized for induction treatment with one of the following three regimens: R 1 = courses of daunorubicin on day 1+ARA-C on days 1–5; R 2 = courses of daunorubicin on days 1 and 2+ARA-C on days 4–8; R 3 = courses of daunorubicin-DNA complex on days 1–2+ ARA-C on days 4–8.
Out of 14 patients, 9 went into remission on R 1, 6 out of 14 on R 2, and 8 out of 16 on R 3. The preliminary results suggest that daunorubicin-DNA complex has the same efficacy for inducing remission as daunorubicin alone, if the same time intervals and dosages are used.
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Gahrton, G., Björkholm, M., Brenning, G. et al. Treatment of acute nonlymphoblastic leukemia in adults with daunorubicin-DNA complex: A preliminary report. Cancer Chemother. Pharmacol. 2, 73–76 (1979). https://doi.org/10.1007/BF00253109
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DOI: https://doi.org/10.1007/BF00253109