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Cooperative study on arterial regional chemotherapy for primary liver cancer in Hokkaido

  • First International Symposium on Treatment of Liver Cancer Kobe, Japan, 15–16 November 1987 Session 2: Chemotherapy, Immunotherapy and Radiotherapy
  • Hepatocellular Carcinoma, Chemoembolization of Hepatic Artery, Targeting Chemotherapy, Adriamycin
  • Published:
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Summary

The Liver Study Group of Hokkaido analyzed a total of 57 patients with non-resectable primary liver cancers, which were treated by intra-arterial adriamicin infusion chemotherapy combined with lipiodol and/or the Gelform embolization of the hepatic arteries. Of the ten patients considered clinical responders, three complete response patients and seven partial response cases were obtained. The overall response rate was 17.5%. The median survival period at each clinical stage was as follows: stage I: 13.0 months, stage II: 16.0 months, stage III: 11.5 months and stage IV: 4.7 months. The common side-effects of this treatment were nausea, vomiting and anorexia. Hematological toxicities were also found, but there was no patient who suffered from severe complications.

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References

  1. Konno T, Maeda H, Iwai K, et al. (1983) Effect of arterial administration of high molecular weight anticancer agent smancs with lipid lymphographic agent on hepatoma. A preliminary report. Eur J Cancer Clin Oncol 19: 1065

    Google Scholar 

  2. Liver Cancer Study Group of Japan (1984) Primary liver cancer in Japan. Cancer 54: 1747

    Google Scholar 

  3. Nagasue N, Yukaya H, Hamada T, et al. (1984) The natural history of hepatocellular carcinoma — a study of 100 untreated cases. Cancer 54: 146

    Google Scholar 

  4. Okuda K, Obata H, Nakajima Y, et al. (1984) Prognosis of primary hepatocellular carcinoma. Hepatology 4: 3S–6S

    Google Scholar 

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Authors and Affiliations

  1. 2nd Dept. of Surgery, Asahikawa Medical College, 4-5 Nishi-Kagura, Asahikawa, Japan

    Mitsuo Kusano & Michio Mito

  2. Dept. of Surgery, Sapporo City General Hospital, Sapporo, Japan

    Masami Nakanishi

  3. 3rd Dept. of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan

    Takashi Matsushima

  4. 1st Dept. of Surgery, Hokkaido University, School of Medicine, Sapporo, Japan

    Yoshie Une

  5. 1st Dept. of Internal Medicine, Sapporo Medical College, Sapporo, Japan

    Mitsuo Suga

  6. 3rd Dept. of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan

    Chihiro Sekiya & Yuuji Ishikawa

  7. Dept. of Gastroenterology, Sapporo Kosei Hospital, Sapporo, Japan

    Shouichi Horita

  8. Dept. of Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan

    Akio Kawamura

  9. Dept. of Internal Medicine, Hokkaido Prefectural Kitano Hospital, Sapporo, Japan

    Shin-ichi Sakamoto

  10. Dept. of Surgery, Asahikawa Kosei Hospital, Asahikawa, Japan

    Junji Fujisawa

  11. Dept. of Radiology, Asahikawa Municipal Hospital, Asahikawa, Japan

    Yoichi Uekita

Authors
  1. Mitsuo Kusano
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  2. Michio Mito
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  3. Masami Nakanishi
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  4. Takashi Matsushima
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  5. Yoshie Une
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  6. Mitsuo Suga
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  7. Chihiro Sekiya
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  8. Yuuji Ishikawa
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  9. Shouichi Horita
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  10. Akio Kawamura
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  11. Shin-ichi Sakamoto
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  12. Junji Fujisawa
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  13. Yoichi Uekita
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Kusano, M., Mito, M., Nakanishi, M. et al. Cooperative study on arterial regional chemotherapy for primary liver cancer in Hokkaido. Cancer Chemother. Pharmacol. 23 (Suppl 1), S17–S20 (1989). https://doi.org/10.1007/BF00647232

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  • DOI: https://doi.org/10.1007/BF00647232

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