Summary
Results of the BMF study group trials ALL-REZ 83 and 85 for relapsed acute lymphoblastic leukemia (ALL) are presented. For children with late marrow relapse, remission rates of about 90% were seen in both studies. In children treated for early marrow relapse, the remission rate in study ALL-REZ 85 was superior (86% vs 62%). The probability of event-free survival for all patients and for those with early marrow relapse was also statistically significant (P<0.05). Children with T-cell ALL had an extremely unfavourable prognosis in both studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amadori S, Spiriti MAA, Meloni G, Pacilli L, Papa G, Mandelli F (1981) Combination chemotherapy for marrow relapse in children and adolescents with acute lymphocytic leukemia. Scand J Haematol 26: 292–296
Baum E, Nachmann J, Ramsey N, Weetman B, Neerhout R, Littman P, Griffin T, Norris D, Sather H (1983) Prolonged second remissions in childhood acute lymphocytic leukemia: a report from The Children's Cancer Study Group. Med Pediatr Oncol 11: 1–7
Butturini A, Bortin M, Rivera G, Gale R (1987) Which treatment for childhood acute lymphoblastic leukaemia in second remission. Lancet I: 429–432
Chessells J, Leiper A, Rogers D (1984) Outcome following late marrow relapse in childhood acute lymphoblastic leukemia. J Clin Oncol 2: 1088–1091
Chessells J, Leiper A, Plowman P, Levinsky R, Rogers D, Blacklock H, Richards S, Festenstein H (1986) Bone-marrow transplantation has a limited role in prolonging second marrow remission in childhood lymphoblastic leukaemia. Lancet I: 1239–1241
Ekert H, Ellis WM, Water KD, Matthews RN (1979) Poor outlook for childhood acute lymphoblastic leukaemia with relapse. Med J Aust 2: 224–226
Feldges A, Imbach P, Lüthy A, Plüss HJ, Sartorius J, Wyss M, Wagner HP (1982) Chance einer Zweitremission bei prognostisch günstiger kindlicher akuter lymphoblastischer Leukämie. SMW 112: 1070–1073
Kremens B, Schwamborn D, Jürgens H, Göbel U (1986) Behandlungsmöglichkeiten des ersten Rezidivs einer akuten lymphoblastischen Leukämie im Kindesalter. Med Welt 37: 936–939
Riehm H, Gadner H, Henze G, Langermann H, Odenwald E (1980) The Berlin childhood acute leukemia therapy study, 1970–1976. AJPHO 2: 299–306
Rivera G, Buchanan G, Boyett J, Camitta B, Ochs J, Kalwinsky D, Amylon M, Vietti TJ, Christ WM (1986) Intensive retreatment of childhood acute lymphoblastic leukemia in first bone marrow relapse: a Pediatric Oncology Group study. N Engl J Med 315: 273–278
Sanders J, Thomas E, Buckner C, Doney K (1987) Marrow transplantation for children with acute lymphoblastic leukemia in second remission. Blood 70: 324–326
Author information
Authors and Affiliations
Additional information
Supported by the Deutsche Krebshilfe e. V.
Rights and permissions
About this article
Cite this article
Henze, G., Fengler, R., Hartmann, R. et al. Chemotherapy for bone marrow relapse of childhood acute lymphoblastic leukemia. Cancer Chemother. Pharmacol. 24 (Suppl 1), S16–S19 (1989). https://doi.org/10.1007/BF00253232
Issue Date:
DOI: https://doi.org/10.1007/BF00253232