Skip to main content
SpringerLink
Log in

Characterization of the anti-tumour activity against solid tumours of a new nitrosoureido sugar: Cy 233

  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

The anti-tumour properties of Cy 233, a new nitrosoureido sugar, were investigated in two murine solid tumours: B16 melanoma and subcutaneously implanted colon adenocarcinoma. Injected i.v., Cy 233 exerted a strong anti-tumour effect against the established B16 melanoma: long-term survivors were recorded with all schedules of treatment. The drug was even more effective against advanced colon 38 adenocarcinoma: it produced a high percentage of total tumour regression, regardless of the route of administration (i.p., i.v., p.o.). The marked in vivo activity of Cy 233 against advanced colon 38 adenocarcinoma, which is known to be resistant to such major anti-cancer drugs as BCNU and chlorozotocin, its water solubility and its stability in aqueous media are further elements warranting toxicological and clinical studies of this agent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aoshima M, Sakurai Y (1977) Comparative studies on the antitumor activity and the bone marrow toxicity of 1-(β-Δ-glucopyranosyl)-3-(2-chloroethyl)-3-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-Δ-glucopyranose. Jpn J Cancer Res 68: 247

    Google Scholar 

  2. Atassi G, Briet P, Berthelon J, Collonges F (1985) Synthesis and antitumor activity of some 8-substituted 4-oxo-4H-1-benzopyrans. Eur J Med Chem-Clin Ther 20: 393

    Google Scholar 

  3. Idanami K, Komiyama K, Kuroda T, Umezawa I (1984) Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors. Cancer Chemother Pharmacl 13: 22

    Google Scholar 

  4. Fox PA, Panasci LC, Schein PS (1977) Biological and chemical properties of 1-(2-chloroethyl)-3-(β-Δ-glucopyranosyl)-1-nitrosourea (NSC-254157), a nitrosourea with reduced bone marrow toxicity. Cancer Res 37: 783

    Google Scholar 

  5. Fujimoto S, Ogawa M (1982) A new nitrosourea derivative TA-077, 1-(-2-chloroethyl)-3-isobutyl-3-(β-maltosyl)-1-nitrosourea: I. Comparative study on anti-tumour activity. Cancer Chemother Pharmacol 9: 134

    Google Scholar 

  6. Geran GI, Greenberg NR, Macdonald MM, Schumacher AM, Abbott BJ (1972) Protocols for screening chemical agents and natural products against animal tumours and other biological systems. Cancer Chemother Rep 3: 11

    Google Scholar 

  7. Gorbacheva LB, Kukuschkina GV (1970) Some aspects of the mechanism of action of 1-propyl-1-nitrosourea. Biochem Pharmacol 19: 1561

    Google Scholar 

  8. Gosse C, El Abed I, Gouyette A, Atassi G, Ardouin P, Roger P (1988) Preliminary pharmacological properties and chemical stability of Cy 233 (NSC-609224). Abstract of the 8th International Symposium on Future Trends in Chemotherapy, Tirrenia, Italy, March 1988

  9. Griswold DP Jr (1972) Consideration of the subcutaneously implanted B16 melanoma as a screening model for potential anticancer agents. Cancer Chemother Rep 3: 315

    Google Scholar 

  10. Komiyama K, Edanami K, Kuroda T, Umezawa I (1981) antitumor effect of 3-[3-(2-chloroethyl)-3-nitrosoureido]-3-deoxy-d-glucopyranose on murine tumors. Jpn J Cancer Res 72: 53

    Google Scholar 

  11. Molineux G, Schofield R, Testa NG (1987) Hematopoietic effects of TNCU in mice. Cancer Treat Rep 71: 837

    Google Scholar 

  12. Roger P, Monneret C, Fournier JP, Choay P, Gagnet R, Gosse C, Letourneux Y, Atassi G, Gouyette A (1989) Rationale for the synthesis and preliminary biological evaluation of highly active new antitumor nitrosoureido sugars. J Med Chem 32: 16

    Google Scholar 

  13. Sasaki K, Aisawa S, Satomi T, Akutsu H, Kawabata S, Momoki Y (1980) Synthesis and antitumor activity ofN-nitrosoureido derivatives of kanosamine. J Antibiot 33: 517

    Google Scholar 

  14. Schabel FM Jr, Johnston TP, McCaleb GS (1963) Experimental evaluation of potential anticancer agents: VIII. Effect of certain nitrosoureas on intracerebral L1210 leukemia. Cancer Res 23: 725

    Google Scholar 

  15. Sedido S, Ninomeya K, Iwasaki M (1979) Biologic activity of MCNU: a new antitumor agent. Cancer Treat Rep 63: 961

    Google Scholar 

  16. Smyth J, Warington P, Cornbleet M, Leonard R (1985) Phase one trial of a novel nitrosourea, TCNU. Third European Conference on Clinical Oncology and Cancer Nursing, June 16–20 Stockholm, p 8

  17. Staquet MJ, Byar DP, Green SB, Rozencweig M (1983) Clinical predictivity of transplantable tumor systems in the selection of new drugs for solid tumors. Rationale for a three-stage strategy. Cancer Treat Rep 67: 753

    Google Scholar 

  18. Sugiura K (1967) Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors. Cancer Res 27: 179

    Google Scholar 

  19. Venditti JM, Wesley RA, Plowman J (1984) Current NCI preclinical antitumor screening in vivo: results of tumor panel screening 1976–1982 and future directions. In: Garattini S, Goldin A, Hawking F (eds) Advances in pharmacology and chemotherapy 20. Academic Press, New York, pp 1–20

    Google Scholar 

  20. Vibe-Petersen J, Bork E, Moller H, Hansen HH, Cornbleet M, Smyth J (1986) Early clinical experience with TCNU — a new water-soluble nitrosourea compound. Proc Am Soc Clin Oncol 5: 31

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Jules Bordet, Centre de Tumeurs de l'Université Libre de Bruxelles, 1 rue Héger-Bordet, B-1000, Bruxelles, Belgium

    G. Atassi & P. Dumont

  2. Pavillon de Recherche, Institut Gustave-Roussy, F-94805, Villejuif Cedex, France

    C. Gosse & A. Gouyette

  3. Faculté des Sciences Pharmaceutiques et Biologiques, F-75270, Paris Cedex 06, France

    J. P. Fournier

  4. Département de Chimie Thérapeutique, Institut Choay-Sanofi Recherche, 10 rue Morel, F-92120, Montrouge, France

    P. Roger

Authors
  1. G. Atassi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Dumont
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Gosse
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. P. Fournier
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Gouyette
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Roger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atassi, G., Dumont, P., Gosse, C. et al. Characterization of the anti-tumour activity against solid tumours of a new nitrosoureido sugar: Cy 233. Cancer Chemother. Pharmacol. 25, 205–209 (1989). https://doi.org/10.1007/BF00689584

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00689584

Keywords

Search

Navigation