Skip to main content

Advertisement

Log in

Immune mechanisms in uveitis

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. 1.al-Sabbagh A, Miller A, Santos LM, Weiner HL (1994) Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol 24:2104

    Google Scholar 

  2. Albert DM, Diaz-Rohena R (1989) A historical review of sympathetic ophthalmia and its epidemiology. Suiv Ophthalmol 34:1

    Google Scholar 

  3. Blanas E, Carbone FR, Allison J, Miller IF, Heath WR (1996) Induction of autoimmune diabetes by oral administration of autoantigen. Science 274:1707

    Google Scholar 

  4. Caspi RR (1992) Immunogenetic aspects of clinical and experimental uveitis. Reg Immunol 4:321

    Google Scholar 

  5. Caspi RR (1994). In: Cohen IR, Miller A (eds) Animal models for autoimmune diseases: a guidebook. Academic Press, New York p 57–81

    Google Scholar 

  6. Caspi RR, Roberge FG, McAllister CG, el Saied M, Kuwabara T, Gery I, Hanna E, Nussenblatt RB (1986) T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol 136:928

    Google Scholar 

  7. Caspi RR, Roberge FG, Nussenblatt RB (1987) Organ-resident, nonlymphoid cells suppress proliferation of autoimmuneT-helper lymphocytes. Science 237:1029

    Google Scholar 

  8. Caspi RR, Chan CC, Leake WC, Higuchi M, Wiggert B, Chader GJ (1990) Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization. J Autoimmun 3:237

    Google Scholar 

  9. Caspi RR, Grubbs BG, Chan CC, Chader GJ, Wiggert B (1992) Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model: concomitant regulation by MHC and nonMHC genes. J Immunol 148:2384

    Google Scholar 

  10. Caspi RR, Chan CC, Fujino Y, Najafian F, Grover S, Hansen CT, Wilder RL (1993) Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis. J Neuroimmunol 47:177

    Google Scholar 

  11. Caspi RR, Silver PB, Chan CC, Sun B, Agarwal RK, Wells J, Oddo S, Fujino Y, Najafian F, Wilder RL (1996) Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Thl response. J Immunol 157:2668

    Google Scholar 

  12. Chambers CA, Allison JP (1997) Co-stimulation in T cell responses. Curr Opin Immunol 9:396

    Google Scholar 

  13. Chan CC, Caspi RR, Ni M, Leake WC, Wiggert B, Chader GJ, Nussenblatt RB (1990) Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun 3:247

    Google Scholar 

  14. Clardy J (1995) The chemistry of signal transduction. Proc Natl Acad Sci USA 92:56

    Google Scholar 

  15. D'Orazio TJ, Niederkom JY (1998) A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160:2089

    Google Scholar 

  16. Davies JM (1997) Molecular mimicry: can epitope mimicry induce autoimmune disease? Immunol Cell Biol 75:113

    Google Scholar 

  17. Dick AD, Cheng YF, McKinnon A, Liversidge J, Forrester JV (1993) Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens. Br J Ophthalmol 77:171

    Google Scholar 

  18. Egwuagu CE, Charukamnoetkanok P, Gery I (1997) Thymic expression of autoantigens correlates with resistance to autoimmune disease. J Immunol 159:3109

    Google Scholar 

  19. Gery I, Mochizuki M, Nussenblatt RB (1986) Retinal specific antigens and immunopathogenic processes they provoke. Prog Retinal Res 5:75

    Google Scholar 

  20. Gregerson DS, Fling SP, Obritsch WF, Merryman CF, Donoso LA (1989) Identification of T cell recognition sites in S-antigen: dissociation of proliferative and pathogenic sites. Cell Immunol 123:427

    Google Scholar 

  21. Gregerson DS, Obritsch WF, Donoso LA (1993) Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols. J Immunol 151:5751

    Google Scholar 

  22. Griffith TS, Yu X, Hemdon JM, Green DR, Ferguson TA (1996) CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5:7

    Google Scholar 

  23. 23.Guex-Crosier Y, Raber J, Chan CC, Kriete MS, Benichou J, Pilsen RS, Kerwin JA, Waldmann TA, Hakimi J, Roberge FG (1997) Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases. J Immunol 158:452

    Google Scholar 

  24. Hara Y, Caspi RR, Wiggert B, Chan CC, Streilein JW (1992) Use of ACAID to suppress interphotoreceptor retinoid binding protein-induced experimental autoimmune uveitis. Curr Eye Res 11:97

    Google Scholar 

  25. Helbig H, Gurley RC, Palestine AG, Nussenblatt RB, Caspi RR (1990) Dual effect of ciliary body cells on T lymphocyte proliferation. Fur J Immunol 20:2457

    Google Scholar 

  26. Hoey S, Grabowski PS, Ralston SH, Forrester JV, Liversidge J (1997) Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma-dependent mechanism. J Immunol 159:5132

    Google Scholar 

  27. Jones LS, Rizzo LV, Agarwal RK, Tarrant TK, Chan CC, Wiggert B, Caspi RR (1997) Interferon gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol 158:5997

    Google Scholar 

  28. Kelso A (1995) Th1 and Th2 subsets: paradigms lost? Immunol Today 16:374

    Google Scholar 

  29. Koevary SB, Caspi RR (1997) Prevention of experimental autoimmune uveoretinitis by intrathymic S- antigen injection. Ocul Immunol Inflamm 5:165

    Google Scholar 

  30. Lafaille JJ, Keere FV, Hsu AL, Baron JL, Haas W, Raine CS, Tonegawa S (1997) Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 186:307

    Google Scholar 

  31. Li Q, Fujino Y, Caspi RR, Najafian F, Nussenblatt RB, Chan CC (1992) Association between mast cells and the development of experimental autoimmune uveitis in different rat strains. Clin Immunol Immunopathol 65:294

    Google Scholar 

  32. Li XY, D'Orazio LT, Niederkorn JY (1996) Role of Th1 and Th2 cells in anterior chamber-associated immune deviation. Immunology 89:34

    Google Scholar 

  33. Miller JF, Basten A (1996) Mechanisms of tolerance to self. Curr Opin Immunol 8:815

    Google Scholar 

  34. Miller SD, McRae BL, Vanderlugt CL, Nikcevich KM, Pope JG, Pope L, Karpus WJ (1995) Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol Rev 144:225

    Google Scholar 

  35. Mosmann TR, Coffman RL (1989) Th1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145

    Google Scholar 

  36. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348.

    Google Scholar 

  37. Nussenblatt RB, Whitcup SM, Palestine AG (1996) Uveitis: fundamentals and clinical practice, 2nd edn. Mosby - Year Book, St. Louis

    Google Scholar 

  38. Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM (1997) Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial [see comments]. Am J Ophthalmol 123:583

    Google Scholar 

  39. Prendergast RA, Iliff CE, Coskuncan NM, Caspi RR, Sartani G, Tarrant TK, Lutty GA, McLeod DS (1998) T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 39:754

    Google Scholar 

  40. Quesniaux VF (1993) Immunosuppressants: tools to investigate the physiological role of cytokines. Bioessays 15:731

    Google Scholar 

  41. Rizzo LV, Silver PB, Hakim F, Chan CC, Wiggert B, Caspi RR (1993) Establishment and characterization of an IRBP-specific T cell line that induces eau in 1310. A mice. Invest Ophthalmol Vis Sci 34 [Suppl]:1143

    Google Scholar 

  42. Rizzo LV, Miller-Rivero NE, Chan CC, Wiggert B, Nussenblatt RB, Caspi RR (1994) Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Invest 94:1668

    Google Scholar 

  43. Rizzo LV, Xu H, Chan C-C, Wiggert B, Caspi RR (in press) IL-10 has a protective role in experimental autoimmune uveitis. Int Immunol

  44. Roman M, Martin-Orozco E, Goodman S, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E (1997) Immunostimulatory DNA sequences function as T helper- I -promoting adjuvants. Nature Med 3:849

    Google Scholar 

  45. Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B (1993) TH2 activated cells prevent experimental autoimmune uveoretinitis, a Th1-dependent autoimmune disease. Eur J Immunol 23:3096

    Google Scholar 

  46. Segal BM, Klinman DM, Shevach EM (1997) Microbial products induce autoimmune disease by an IL12-dependent pathway. J Immunol 158:5087

    Google Scholar 

  47. Singh VK, Kalra HK, Yamaki K, Abe T, Donoso LA, Shinohara T (1990) Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides. Induction of experimental autoimmune uveitis in Lewis rats. J Immunol 144:1282

    Google Scholar 

  48. Streilein JW, Wilbanks GA, Taylor A, Cousins S (1992) Eye-derived cytokines and the immunosuppressive intraocular microenvironment: a review. Curr Eye Res 11:41

    Google Scholar 

  49. Streilein JW, Takeuchi M, Taylor AW (1997) Immune privilege, T-cell tolerance, and tissue-restricted autoimmunity. Hum Immunol 52:138

    Google Scholar 

  50. Sun B, Rizzo LV, Sun SH, Chan CC, Wiggert B, Wilder RL, Caspi RR (1997) Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper- l-like or a T helper-2-like response. J Immunol 159:1004

    Google Scholar 

  51. Tarrant TK, Silver PB, Chan C-C, Wiggert B, Caspi RR (in press) Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J Immunol

  52. Waldmann TA, Pastan IH, Gansow OA, Junghans RP (1992) The multichain interleukin-2 receptor: a target for immunotherapy. Ann Intern Med 116:148

    Google Scholar 

  53. Weiner HL (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18:335

    Google Scholar 

  54. Whitcup SM, DeBarge LR, Caspi RR, Harning R, Nussenblatt RB, Chan CC (1993) Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis. Clin Immunol Immunopathol 67:143

    Google Scholar 

  55. Wildner G, Thurau SR (1994) Cross-reactivity between an HLA-1327-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex associationwith autoimmune disease. Eur J Immunol 24:2579

    Google Scholar 

  56. Wildner G, Thurau SR (1995) Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye. Eur J Immunol 25:1292

    Google Scholar 

  57. Wu GS, Zhang J, Rao NA (1997) Peroxynitrite and oxidative damage in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 38:1333

    Google Scholar 

  58. Xiao BG, Link H (1997) Mucosal tolerance: a two-edged sword to prevent and treat autoimmune diseases. Clin Immunol Immunopathol 85:119

    Google Scholar 

  59. Xu H,, Rizzo LV, Silver PB, Caspi RR (1997) Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of primary and committed T cells in EAU. Cell Immunol 178:69

    Google Scholar 

  60. Xu H, Wawrousek EF, Redmond TM, Nickerson JM, Wiggert B, Chan C-C, Caspi RR (1998) Extraocular expression of the retinal antigen reduces the susceptibility to experimental autoimmune uveoretinitis in IRBP transgenic mice. Invest Ophthalmol Vis Sci [Suppl] (in press)

  61. Silver PB, Tarrant TK, Chan CC, Wiggert B, Caspi RR. Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis. Invest Opthalmol Vis Sci (in press)

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Caspi, R.R. Immune mechanisms in uveitis. Springer Semin Immunopathol 21, 113–124 (1999). https://doi.org/10.1007/BF00810244

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00810244

Keywords

Navigation