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Plasminogen activation in plasma of patients with systemic lupus erythematosus

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Summary

We measured α2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P<0.001) and the SLE patients with nephrotic syndrome had higher plasma PI-PC levels than those without nephrotic syndrome (P<0.01). In addition, the plasma PI-PC level was significantly correlated with the level of plasma C3 breakdown products (iC3b/C3dg) in the patients with SLE (r=0.53, P<0.01). These results suggest that plasminogen is activated in plasma of patients with SLE and that the plasminogen activation may be associated with the activation of complement in SLE.

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Authors and Affiliations

  1. First Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-Machi, Abeno-Ku, 545, Osaka, Japan

    N. Negoro, Y. Kanayama, T. Takeda, M. Fujisawa, M. Okamura & T. Inoue

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  1. N. Negoro
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  2. Y. Kanayama
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  3. T. Takeda
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  4. M. Fujisawa
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  5. M. Okamura
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  6. T. Inoue
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Negoro, N., Kanayama, Y., Takeda, T. et al. Plasminogen activation in plasma of patients with systemic lupus erythematosus. Rheumatol Int 8, 273–277 (1989). https://doi.org/10.1007/BF00270984

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  • DOI: https://doi.org/10.1007/BF00270984

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