Abstract
Over the past 5 years we have used the new dimeric, non-ionic, water-soluble contrast agent iotrolan (Isovist-300) in 370 studies of the paediatric gastrointestinal tract. Iotrolan is by far the best accepted and tolerated contrast agent for young children. Because of its iso-osmolality it can be used without dilution. No ill effects were reported in cases of aspiration or perforation. In all studies very high contrast images were obtained and the required diagnostic information was provided. The only disadvantage of iotrolan is its present high price. However, in view of the small volumes required in children (10 ml is sufficient in 59% and 20 ml sufficient in 92% of investigations) this should not be a major obstacle to its use. Iotrolan promotes a much greater readiness among paediatricians and paediatric surgeons to have gastrointestinal studies performed on very small and very sick babies.
Similar content being viewed by others
References
Cohen MD, Smith WL, Smith JA, Gresham EL, Schreiner R, Lemons J (1987) The use of metrizamide (Amipaque) to visualize the gastrointestinal tract in children: a preliminary report. Clin Radiol 31: 635–641
Langer R, Kaufmann HJ (1989) Nonionic contrast media in gastrointestinal studies in newborns and small infants. In: Taenzer V, Wende S (eds) Recent developments in nonionic contrast media. Thieme, Stuttgart, pp 200–203
Bassir C, Kaufmann HJ (1990) Iotrolan study of the GI-tract in newborns and babies. Pediatr Radiol 20: 410
Cohen MD (1987) Choosing contrast media for the evaluation of the gastrointestinal tract of neonates and infants. Radiology 162: 447–456
Gelfand DW (1980) Complications of gastrointestinal radiologic procedures. 1. Complications of routine fluoroscopic studies. Gastrointest Radiol 5: 293
McAlister WH, Siegel MJ (1984) Fatal aspirations in infancy during gastrointestinal series. Pediatr Radiol 14: 81–83
Elke M (1992) Kontrastmittel in der radiologischen Diagnostik: Eigenschaften, Nebenwirkungen, Behandlung. Thieme, Stuttgart, p 171
Zieger B, Brinkmann H, Tröger J, Alzen G, Fendel H, Lassrich MA, Kaufmann HJ, Schuster W (1988) Ein neues Kontrastmittel für die Magen-Darm-Diagnostik: Solutrast Gastro: Klinische Prüfung in der Pädiatrischen Radiologie. Röntgenpraxis 41: 353–357
Friedmann BJ, Hartenberg MA, Mulroy JJ, Tong TK, Mickell JJ (1986) Gastrografin aspiration in a\(3{\raise0.5ex\hbox{$\scriptstyle 3$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle 4$}}\)-year-old girl. Pediatr Radiol 16: 506–507
Ratcliffe JF (1986) The use of low osmolality water soluble (LOWS) contrast media in the pediatric gastro-intestinal tract: a report of 115 examinations. Pediatr Radiol 16: 47–52
Miyazawa T, Sho C, Nakagawa H, Oshino N (1990) Effect of water-soluble contrast medium on the lung in rats: comparison of iotrolan, iopamidol, and diatrizoate. Invest Radiol 25: 999–1003
Gmeinwieser J, Golder W, Lehner K, Bartels H (1988) Réntgendiagnostik des oberen Gastrointestinaltraktes bei Aspirationsgefahr mit einem nicht-ionischen isoosmolaren Kontrastmittel. Röntgenpraxis 41: 361–366
Riebel T, Wenzel-Hora BI (1990) Use of non-ionic contrast media for tracheobronchography in neonates and young infants. Eur J Radiol 11: 120–124
Cohen MD (1990) Choosing contrast media for the pediatric gastrointestinal examinations. Crit Rev Diagn Imaging 30: 317–340
Tröger J, Wenzel-Hora BI (1989) Gastrointestinal diagnosis with iotrolan: experience in pediatric radiology. Fortschr Geb Röntgenstr Nuklearmed Ergänzungsbd 128:195–199
Stordahl A, Laerum F (1988) Water-soluble contrast media compared with barium in enteric follow-through: urinary excretion and radiographic efficacy in rats with intestinal ischemia. Invest Radiol 23: 471–477
Laerum F, Stordahl A, Aase S (1988) Water-soluble contrast media compared with barium in enteric follow-through: local effects and radiographic efficacy in rats with simple obstruction of the small bowel. Acta Radiol 29: 603–610
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bassir, C., Riebet, T., Nasir, R. et al. Long-term experience in using iotrolan for paediatric gastrointestinal studies. Eur. Radiol. 4, 371–376 (1994). https://doi.org/10.1007/BF00599073
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00599073