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Experimental cerebral ischemia in Mongolian gerbils

I. Light microscopic observations

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Summary

Light microscopic observations were carried out on Mongolian gerbils (Meriones unguiculatus) subjected to a partial cerebral ischemia by occlusion of the left common carotid artery at the neck. About 30% of gerbils developed an ischemic injury in the ipsilateral hemisphere and their brains revealed the following histopathologic features: 1. the changes were related to the intensity (duration) of the ischemic insult and to the time elapsed following release of the occlusion. The ischemic lesions appear to progress after re-establishment of the circulation and this presents one facet of a “maturation” phenomenon which seems to be a general principle applicable to various parameters of ischemic injury. The rate of “maturation” of the lesions is related to the intensity of the ischemic insult, a lesser intensity resulting in longer development of lesions. 2. The changes were either focal or diffuse in character. The former were assumed to be directly related to a vascular involvement; among the latter the topistic distribution of the hippocampal changes suggested a feature of selective vulnerability. 3. An indirect indication of neuronal recovery was surmised from observations on animals sacrificed after different periods following occlusions of the same duration. Also capable of recovery was a “reactive change” observed in the H3 neurons of the hippocampus. This change was characterized by central chromatolysis and resembled the “primäre Reizung” of Nissl.

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References

  • Brierley, J. B.: Pathology of cerebral ischemia. In: Cerebral vascular disease, F. H. McDowel, and R. W. Brennan (eds.), pp. 59–75. New York-London: Grune and Stratton Publ. 1973

    Google Scholar 

  • Greenfield, J. G.: General pathology of the nerve cell and neuroglia. In: Neuropathology, J. G. Greenfield, W. Blackwood, W. H. McMenemey, A. Meyer and R. M. Norman, (eds.), pp. 1–6. London: Edward Arnold Publ. 1958

    Google Scholar 

  • Hydén, H.: Protein metabolism in the nerve cell during growth and function. Acta physiol. scand.6, 88–97 (1943)

    Google Scholar 

  • Ito, U., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. IV. Noreflow phenomenon. (In preparation)

  • Ito, U., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. III. Behaviour of the blood-brain barrier. (In preparation)

  • Kahn, K.: The natural course of experimental cerebral infarction in the gerbil. Neurology (Minneap.)22, 510–516 (1972)

    Google Scholar 

  • Mrsulja, B. B., Mrsulja, B. J., Ito, U., Spatz, M., Klatzo, I.: Experimental cerebral ischemia Mongolian gerbils. II. Carbohydrate changes. (In preparation)

  • Mrsulja, B. B., Mrsulja, B. J., Ito, U., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. V. Behaviour of biogenic amines. (In prearation)

  • Mrsulja, B. J., Bubis, J., Mrsulja, B. B., Ito U., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. VI. Histochemical observations on the “reactive change” in the hippocampus. (In preparation)

  • Nissl, F.: Über die Veränderungen der Ganglienzellen am Facialiskern des Kaninchens nach Ausreißung der Nerven. Allg. Z. Psychiat.48, 197–206 (1892)

    Google Scholar 

  • Scholz, W.: Für die allgemeine Histopathologie degenerativer Prozesse bedeutsame morphologische, histochemische und structurphysiologische Daten. In: Handbuch der speziellen pathologischen Anatomie und Histologie. XIII. Nervensystem, I. A. Band, O. Lubarsch, F. Henke and R. Rössle (Hrsg.), pp. 42–266. Berlin-Göttingen-Heidelberg: Springer 1957

    Google Scholar 

  • Vogt, C., Vogt, O.: Erkrankungen der Großhirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik. J. Psychol. Neurol. (Lpz.)28, 9–68 (1922)

    Google Scholar 

  • Zülch, K. J., Behrend, R. C. H.: The pathogenesis and topography of anoxia, hypoxia and ischemia of the brain in man. In: Cerebral Anoxia and Encephalogram, by H. Gastaut and J. S. Meyer (eds.), pp. 144–163. Springfield, Ill.: Ch. C. Thomas 1922

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Neuropathology and Neuroanatomical Sciences National Institute of Neurological Diseases and Stroke, National Institutes of Health, 20014, Bethesda, Maryland, USA

    U. Ito, M. Spatz, J. T. Walker Jr. & I. Klatzo

Authors
  1. U. Ito
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  2. M. Spatz
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  3. J. T. Walker Jr.
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  4. I. Klatzo
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Ito, U., Spatz, M., Walker, J.T. et al. Experimental cerebral ischemia in Mongolian gerbils. Acta Neuropathol 32, 209–223 (1975). https://doi.org/10.1007/BF00696570

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  • DOI: https://doi.org/10.1007/BF00696570

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