Summary
An unusual case of panencephalitis in a 4-year-old Japanese boy, with onset at three months after measles infection and rapid progression to a comatose state in approximately one month, is described. A rapid rise in serum measles antibody titre after the onset of the symptoms, and the appearance of various abnormal antibodies in the serum, were noted. Pathologically, the brain showed sclerosing polio- and leucoencephalitis with diffuse gliosis and sporadic intranuclear inclusions. The process is suggested to be intermediate or transitional between acute measles encephalitis and SSPE.
References
Adams, J. M.: Clinical pathology of measles encephalitis and sequelae. Neurology (Minneap.)18, 52–56 (1968)
Adams, J. M., Barid, C., Fillory, L.: Inclusion bodies in measles encephalitis. J. Amer. med. Ass.195, 290–298 (1966)
Bell, T. M., Caspray, E. A., Cowshall, S.: Measles virus associated with unusual subacute encephalitis in an infant. J. neurol. Sci.16, 455–463 (1972)
Bouteille, M., Fontaine, C., Vedrenne, C. L.: Sur un cas d'encèphalite subaique à inclusions: Étude anatomoclinique et ultrastructurale. Rev. neurol.113, 454–458 (1965)
Breitfeld, V., Hashida, Y., Sherman, F. E.: Fatal measles infection in children with leukemia. Lab. Invest.28, 279–291 (1973)
Cape, C. A., Martinetz, A. J., Robertson, J. T.: Adult onset of subacute sclerosing panencephalitis. Arch. Neurol. (Chic.)28, 124–127 (1973)
Connolly, J. H., Allen, I. V., Hurwitz, L. J.: Measles virus antibody and antigen in subacute sclerosing panencephalitis. Lancet1967 I, 542–544
Detels, R., Brody, J. A., McNew, J.: Further epidemiological studies of subacute sclerosing panencephalitis. Lancet1973 I, 11–14
Donner, M., Waltimo, O., Porras, J.: Subacute sclerosing panencephalitis as a cause of chronic dementia and relapsing brain disorder. J. Neurol. Neurosurg. Psychiat.35, 180–185 (1973)
Ford, F. R.: Disease of the nervous system in infancy, childhood, and adolescence. Sixth edition, pp. 670–685. Springfield, Ill.: Ch. C. Thomas 1973
Freeman, J. M.: The clinical spectrum and early diagnosis of Dawson's encephalitis. J. Pediat.75, 590–603 (1969)
Gilden, D. H., Rorke, L. B., Tanaka, R.: Acute SSPE. Arch. Neurol. (Chic.)32, 646–664 (1975)
Hanissian, A. S., Jabbour, J. T., deLamerens, S.: Subacute encephalitis and hypogammaglobulinemia. Amer. J. Dis. Child.123, 151–155 (1972)
Horta-Barbosa, L., Fuccillo, D. A., London, W. T.: Isolation of measles virus from brain cell cultures of two patients with subacute sclerosing panencephalitis. Proc. Soc. exp. Biol. (N.Y.)132, 272–277 (1969)
Jabbour, J. T., Duenas, D. A., Modlin, J.: Subacute sclerosing panencephalitis: Clinical staging, course, and frequency, 1975. Arch. Neurol. (Chic.)32, 493–494 (1975)
Jabbour, J. T., Garcia, J. H., Lemmi, H.: Subacute sclerosing panencephalitis. J. Amer. med. Ass.207, 2248–2254 (1969)
Katz, M., Rorke, L. B., Masland, W. S.: Transmission of an encephalitogenic agent from brains of patients with subacute sclerosing panencephalitis to ferrets. New Engl. J. Med.279, 793–798 (1968)
Lowenthal, A., Moya, G., Poire, R.: Subacute sclerosing panencephalitis, a clinical and biological reappraisal. J. neurol. Sci.15, 267–270 (1972)
Resnicke, J. S., Engel, W. K., Sever, J. L.: Subacute sclerosing patient with elevated measles antibody in blood and spinal fluid. New Engl. J. Med.279, 126–129 (1968)
Skhubert, P.: Atypischer Fall einer subakuten sklerosierenden Leukoencephalitis (Van Bogaert). Acta neuropath. (Berl.)6, 93–97 (1966)
Sluga, E., Budka, H., Pichler, E.: Slow-Virus “Enzephalitis” nach Masern bei zytostastisch behandelter Leukämie im Kindesalter. Wien. klin. Wschr.87, 248–251 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nihei, K., Kamoshita, S., Mizutani, H. et al. Atypical subacute sclerosing panencephalitis. Acta Neuropathol 38, 163–166 (1977). https://doi.org/10.1007/BF00688565
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688565