Summary
Describing two new cases of so-called Central Core Disease, the authors revealed certain atypical features: The cores were formed in central as well as in peripheral position; they were observed in some apparently type II fibers; typical “structured” and “unstructured” cores coexisted with “reversed” core.
Starting from this pictures a cycle of core formation was imaginated supposing to be initiated as the consequence of abnormal functional interrelationship between muscular and neural components in early myogenesis.
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This work was supported by a grant of Muscular Dystrophy Association, Inc.
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Radu, H., Rosu-Serbu, A.M., Ionescu, V. et al. Focal abnormalities in mitochondrial distribution in muscle. Acta Neuropathol 39, 25–31 (1977). https://doi.org/10.1007/BF00690382
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DOI: https://doi.org/10.1007/BF00690382