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Microcephaly with peculiar demyelination mimicking Pelizaeus-Merzbacher disease

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Summary

The neuropathological studies of a 4-year old idiot with microcephaly revealed a striking demyelinating disease compatible with Pelizaeus-Merzbacher disease. The case seemed to be best classified as the patchy demyelination type, but the most unusual finding was a prominent vasculature in some demyelinated areas. Intrauterine hypoxia was proposed as a causative factor of this type of demyelinative lesions

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References

  • Bhagavan, B. S., Wagner, J. A., Juvanteguy, J.: Central pontine myelinolysis and medullary myelinolysis. Arch. Path. Lab. Med.100, 246–252 (1976)

    Google Scholar 

  • Brucher, J. M.: Neuropathological problems posed by carbon monoxide poisoning and anoxia. Progr. Brain Res.24, 76–100 (1967)

    Google Scholar 

  • Cadman, T., Rorke, L. B.: Central pontine myelinolysis in childhood and adolescence. Arch. Dis. Childh.44, 342–350 (1969)

    Google Scholar 

  • Courville, C. B.: Relation of diffuse sclerosis to paranatal anoxia. In C. B. Courville: Birth and brain damage, pp. 257–283. Pasadena: Margaret F. Courville 1971

    Google Scholar 

  • Goutieres, F., Aicardi, J., Farkas-Bargeton, E.: Leucoencéphalopathie familiale progressive avec proliferation vasculaire. Ses relations eventuelles avec l'encephalopathie nécrosante subaiguë. Acta Neuropath.28, 143–150 (1974)

    Google Scholar 

  • Guazzi, G. C., Martin, J. J.: La forme infantile de la leucodystrophie sudanophile avec angiomatose méningée non calcifiante. Acta Neurol. Belg.67, 463–474 (1967)

    Google Scholar 

  • Jellinger, K., Seitelberger, F.: Subacute necrotizing encephalomyelopathy (Leigh). Ergebn. Inn. Med. Kinderheilk.29, 155–219 (1970)

    Google Scholar 

  • Lapresle, J., Fardeau, M.: Les leuco-encéphalopathie de l'intoxication oxycarbonée. Acta Neuropath.6, 327–348 (1966)

    Google Scholar 

  • Seitelberger, F.: Pelizaeus-Merzbacher disease. In: P. J. Vinken and G. W. Bruyn: Handbook of clinical neurology, Vol. 10, Leucodystrophies and poliodystrophies, pp. 150–202. Amsterdam: North Holland 1970

    Google Scholar 

  • Wender, M.: Studies of cerebral lipids in a relapsing case of carbon monoxide poisoning. Acta Neuropath.2, 371–377 (1963)

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Jichi Medical School, Tochigi, Japan

    S. Kamoshita & M. Igarashi

  2. Tokyo Metropolitan Medical Examiner's Office, Tokyo, Japan

    R. Kohno

Authors
  1. S. Kamoshita
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  2. M. Igarashi
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  3. R. Kohno
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Kamoshita, S., Igarashi, M. & Kohno, R. Microcephaly with peculiar demyelination mimicking Pelizaeus-Merzbacher disease. Acta Neuropathol 40, 95–98 (1977). https://doi.org/10.1007/BF00688579

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  • DOI: https://doi.org/10.1007/BF00688579

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