Skip to main content
SpringerLink
Log in

The morphology of lipopigment granules in oligodendrocytes of the cerebellum and spinal cord and in Schwann cells of theN. ischiadicus of the cat, Japanese waltzing mouse, and albino mouse

  • Original Works
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

In the oligodendrocytes of cerebellum and spinal cord and in the Schwann cells of peripheral nerves of cat, albino mouse, and Japanese waltzing mouse lipopigment bodies of different size and shape are deposited, which exhibit a characteristic internal structure. The following three subtypes can be distinguished: (1) Granules completely surrounded by a membrane and containing regularly speced lamellae, (2) granules consisting of a granular matrix with elucidations, and (3) granules with bifurcating stacks of lamellae. Thus, their structure is distinct from that found in nerve cells and other glial cells and allows the diagnosis of oligodendrocyte or Schwann cell. The significance of these granules in relation to function and aging is briefly discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Braak H (1970) Über die Kerngebiete des menschlichen Hirnstammes. I. Olivia inferior, Nucleus conterminalis und Nucleus vermiformis corporis restiformis. Z Zellforsch 105:442–456

    Google Scholar 

  • Braak H (1971a) Über die Kerngebiete des menschlichen Hirnstammes. III. Centrum medianum thalami und Nucleus parafascicularis. Z Zellforsch 114:331–343

    Google Scholar 

  • Braak H (1971b) Über das Neurolipofuscin in der unteren Olive und dem Nucleus dentatus cerebelli im Gehirn des Menschen. Z Zellforsch 121:573–592

    Google Scholar 

  • Braak H (1971c) Über die Kerngebiete des menschlichen Hirnstammes. IV. Der Nucleus reticularis lateralis und seine Satelliten. Z Zellforsch 122:145–159

    Google Scholar 

  • Braak H (1974) On the intermediate cells of Lugaro within the cerebellar cortex of man. Cell Tissue Res 149:399–411

    Google Scholar 

  • Braak H (1975) On the Pars cerebellaris loci coerulei within the cerebellum of man. Cell Tissue Res 160:279–282

    Google Scholar 

  • Braak E, Braak H (1980) Age-related alterations of the proximal axon segment in lamina IIIab-pyramidal cells of the human isocortex. A Golgi and fine structural study. J Hirnforsch 21:531–535

    Google Scholar 

  • Braak E, Braak H, Strenge H, Mutaroglu A-U (1980) Pigment-filled appendages of the small spiny neurons: A severe pathological change of the striatum in neuronal ceroid lipofuscinosis. Neuropathol Appl Neurobiol 5:389–394

    Google Scholar 

  • Davies I, Fotheringham A, Roberts C (1983) The effect of lipofuscin on cellular function. Mech Ageing 23:347–356

    Google Scholar 

  • Dayan AD (1971) Comparative neuropathology of ageing. Studies on the brains of 47 species of vertebrates. Brain 94:31–42

    Google Scholar 

  • Elzholz A (1898) Zur Kenntnis der Veränderungen im centralen Stumpfe lädierter gemischter Nerven. Jb Psychiatrie 17:323

    Google Scholar 

  • Fananas J, Ramón JY (1916) Contribution al estudio de la neuroglía del cerebelo. Trab Lab Invest Biol 14:163–179

    Google Scholar 

  • Heinsen H (1979) Lipofuscin in the cerebellar cortex of albino rats: An electron-microscopic study. Anat Embryol 155:333–345

    Google Scholar 

  • Heinsen H (1981) Regional differences in the distribution of lipofuscin in Purkinje cell perikarya. Anat Embryol 161:453–464

    Google Scholar 

  • Herrlinger H, Kronski D, Anzil AP, Blinzinger K (1974) Die frühzeitige transorbitale Nadelautopsie. Eine brauchbare Methode zur Gewebsentnahme für ultrastrukturelle Untersuchungen am menschlichen Stirnhirn. Arch Psychiatr Nervenkr 219:105–115

    Google Scholar 

  • Hess A, Lansing AJ (1953) The fine structure of nerve fibers. Anat Rec 117:175–200

    Google Scholar 

  • Ito S, Winchester RJ (1963) The fine structure of the gastric mucosa in the bat. J Cell Biol 16:541–577

    Google Scholar 

  • Jurecka W, Ammerer HP, Lassmann H (1975) Regeneration of a transected peripheral nerve. An autoradiographic and electron-microscopic study. Acta Neuropathol (Berl) 32: 299–312

    Google Scholar 

  • Monteiro RAF (1981) Neuroglia of rat cerebellar cortex-Identification and distribution. Proc Electron Microscop Soc Southern Africa 11:79–80

    Google Scholar 

  • Monteiro RAF (1983) Do the Pukinje cells have a special type of oligodendrocyte as satellites? J Anat 137:71–83

    Google Scholar 

  • Mugnaini E (1972) The histology and cytology of the cerebellar cortex. In: Larsell O, Jansen J (eds) The comparative anatomy and histology of the cerebellum. The human cerebellum, cerebellar connections, and cerebellar cortex. University of Minnesota Press Minneapolis, pp 245–250

    Google Scholar 

  • Petersen KU (1969) Zur Feinstruktur der Neurogliazellen in der Kleinhirnrinde von Säugetieren. Z Zellforsch 100:616–633

    Google Scholar 

  • Reich F (1902/03) Über eine neue Granulation in den Nervenzellen. Cited by Stoeckenius and Zeiger (1956)

  • Reich F (1907) Über den zelligen Aufbau der Nervenfaser aufgrund mikrohistochemischer Untersuchungen. I. Die chemischen Bestandteile des Nervenmarks, ihr mikrohistochemisches und färberisches Verhalten. Cited by Stoeckenius and Zeiger (1956)

  • Rösler B, Kemnitz P (1983) Beziehungen zwischen dem Lipofuscingehalt und der Organellendichte in den Pyramidenzellen der Laminae III und V der Area 10 (Brodmann) des Lobus frontalis cerebri von Menschen unterschiedlicher Altersstufen. J Hirnforsch 24:415–424

    Google Scholar 

  • Schlote W, Boellaard JW (1983) Role of lipopigment during ageing of nerve and glial cells in the human nervous system. Aging 21:27–74

    Google Scholar 

  • Stoeckenius W, Zeiger K (1956) VIII. Morphologie der segmentierten Nervenfaser. Ergeb Anat 35:420–535

    Google Scholar 

  • Sturrock RR (1980) A comparative quantitative and morphological study of aging in the mouse neostriatum, induseum griseum, and anterior commissure. Neuropathol Appl Neurobiol 6:51–68

    Google Scholar 

  • Vaughan DW, Peters A (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study. J Neurocytol 3:405–429

    Google Scholar 

  • Wall G (1973) Über ein Lipofuscin transportierendes Pigmentzell-System in der Kleinhirnrinde der Katze. Z Anat Entwickl-Gesch 143:13–24

    Google Scholar 

  • Zeiger K, Harders J (1951) Über vitale Fluorochromfärbung des Nervengewebes. Z Zellforsch 36:62–78

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Anatomy, University of Munich, Pettenkoferstr. 11, D-8000, München 2, Germany

    W. Lange & A. Schropp

Authors
  1. W. Lange
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Schropp
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to Prof. Dr. med., Dr. med. h. c. H. Voss on the occasion of his 90th birthday

Supported by the Deutsche Forschungsgemeinschaft (La 184/7)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lange, W., Schropp, A. The morphology of lipopigment granules in oligodendrocytes of the cerebellum and spinal cord and in Schwann cells of theN. ischiadicus of the cat, Japanese waltzing mouse, and albino mouse. Acta Neuropathol 65, 330–334 (1985). https://doi.org/10.1007/BF00687017

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00687017

Key words

Search

Navigation