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Experimental transmission of human subacute spongiform encephalopathy to small rodents

III. Further transmission from three patients and distribution patterns of lesions in mice

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Summary

Further experimental transmission of Creutzfeldt-Jakob disease (CJD) from three patients to mice and rats was carried out successfully. The clinical signs and pathologic features of spongiform encephalopathy transmitted to animals were much the same as in previous experiments, except that distribution of the lesions in the mice differed with each inoculated material taken from the patients. These observations suggest the multiplicity of CJD agents, as in the case of scrapie agents.

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References

  • Fraser H, Dickinson AG (1973) Scrapie in mice. Agent-strain differences in the distribution and intensity of gray matter vacuolation. J Comp Pathol 83:29–40

    Google Scholar 

  • Ishii N, Suzuki T, Nishi E, Koga Y, Takeda T (1978) Two cases of Creutzfeldt-Jakob disease with extensive white matter involvement. Kyushu N-psych 24:227–233

    Google Scholar 

  • Kuroiwa Y, Shii H, Tsuji S, Yamashita Y, Nagara H, Doi H, Tateishi J (1979) An autopsied case of a typical Creutzfeldt-Jakob disease with comparative studies on electrophysiological changes and CT. In: Annual Report of the Ministry of Health and Welfare. Slow Viral Infection Research Committee, pp 30–34

  • Suetsugu M, Moriyama N, Sato Y, Tateishi J, Mitsuyama Y (1980) Pathological findings of one case of Creutzfeldt-Jakob disease with clinical course over 9 years and severe brain atrophy. Kyushu N-psych 26:250–256

    Google Scholar 

  • Tateishi J, Sato Y, Koga M, Doi H, Ohta M (1980) Experimental transmission of human subacute spongiform encephalopathy to small rodents. I. Clinical and histological observations. Acta Neuropathol (Berl) 51:127–134

    Google Scholar 

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Tateishi, J., Doi, H., Sato, Y. et al. Experimental transmission of human subacute spongiform encephalopathy to small rodents. Acta Neuropathol 53, 161–163 (1981). https://doi.org/10.1007/BF00689997

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  • DOI: https://doi.org/10.1007/BF00689997

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