Summary
A case of pallido-nigro-luysial atrophy, characterized by symptoms typical of progressive supranuclear palsy, presented (1) severe symmetrical abiotrophic degeneration of the globus pallidus, substantia nigra, and subthalamic nucleus and (2) widespread accumulations of corpora amylacea in the CNS. The former is thought to be consistent with pallidonigro-luysial atrophy and we regard it as a combined system degeneration of both the pallido-nigral and the pallido-luysial systems. The significance of the latter is quite obscure. As far as we know, only three cases of pallido-nigro-luysial atrophy have been reported. However, there is no reported case of this disorder with such widespread and massive accumulations of corpora amylacea as in our case.
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References
Alder N (1953) On the nature, origin, and distribution of the corpora amylacea of the brain with observations on some new staining reactions. J Ment Sci 99:689–697
Behrman S, Carroll JD, Janota I, Mathews WB (1969) Progressive supranuclear palsy. Clinico-pathological study of four cases. Brain 92:663–678
Contamin F, Escourolle R, Nick J, Mignot B (1971) Atrophie pallido-nigro-luysienne syndrome akinétique avec palialie, rigidité oppositionelle et catatonie. Rev Neurol 124:107–120
David NJ, Mackey EA, Smith JL (1968) Further observations in progressive supranuclear palsy. Neurology (Minneap) 18:349–356
Jellinger K (1968) Degenerations and exogenous lesions of the pallidum and striatum. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 6, North Holland, Amsterdam, pp 632–693
Jellinger K, Neumayer E (1972) Unusual late-onset type of Hallervorden-Spatz disease Clinico-pathological study of a case presenting as parkinsonism. Z Neurol 203:105–118
Ramsey HJ (1965) Ultrastructure of corpora amylacea. J Neuropathol Exp Neurol 24:25–39
Sakai M, Austin J, Witmer F, Treub L (1969) Studies of corpora amylacea. I. Isolation and preliminary characterization by chemical and histochemical techniques. Arch Neurol 21:526–544
Steele JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy. Arch Neurol 10:333–359
Takahashi K, Nakashima R, Takao T, Nakamura H (1977) Pallidonigro-luysial atrophy associated with degeneration of the centrum medianum. A clinicopathologic and electron-microscopic study. Acta Neuropathol (Berl) 37:81–85
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Kosaka, K., Matsushita, M., Oyanagi, S. et al. Pallido-nigro-luysial atrophy with massive appearance of corpora amylacea in the CNS. Acta Neuropathol 53, 169–172 (1981). https://doi.org/10.1007/BF00689999
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DOI: https://doi.org/10.1007/BF00689999