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The localization of glial fibrillary acidic protein in brain tumors induced in hamsters with avian sarcoma virus

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Summary

The immunohistochemical localization of glial fibrillary acidic protein (GFAP) was studied by the peroxidase-antiperoxidase (PAP) method in avian sarcoma virus (ASV)-induced brain tumors in hamsters. One hundred twenty-four tumors including 54 astrocytomas, 64 pleomorphic gliomas, five sarcomas, and one unclassified tumor were stained with anti-GFAP serum. A positive immunostaining was seen in astrocytomas and in pleomorphic gliomas. Sarcomas and an unclassified tumor were negative. These results confirmed that a majority of ASV-induced brain tumors contained neoplastic glial cells, and further suggested that the astrocyte is a main target cell of ASV in the experimental neuro-oncogenesis.

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Authors and Affiliations

  1. Dept. of Pathology, Gunma University School of Medicine, 3-39-22, Showa-machi, 371, Maebashi, Gunma, Japan

    Y. Nakazato, H. Yamaguchi, K. Takahashi & Y. Ishida

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  1. Y. Nakazato
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  2. H. Yamaguchi
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  3. K. Takahashi
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  4. Y. Ishida
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Nakazato, Y., Yamaguchi, H., Takahashi, K. et al. The localization of glial fibrillary acidic protein in brain tumors induced in hamsters with avian sarcoma virus. Acta Neuropathol 55, 293–295 (1981). https://doi.org/10.1007/BF00690993

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  • DOI: https://doi.org/10.1007/BF00690993

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