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Distal symmetric polyneuropathy in the spontaneously diabetic BB-Wistar rat

An ultrastructural and teased fiber study

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Summary

The distal, symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat was studied ultrastructurally and by means of teased fiber preparations. Ultrastructural findings consisted of malorientation of the axonal cytoskeleton, followed by axonal atrophy, secondary myelin breakdown and distal Wallerian degeneration. This sequence of structural changes could be confirmed by scoring of pathological abnormalities and morphometric evaluation of teased fibers. Distal sensory nerve fibers were affected earlier and more severely than motor fibers.

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology, Banting Institute, University of Toronto and Toronto General Hospital, Toronto, Canada

    A. A. F. Sima & A. C. Lorusso

  2. Animal Resources Division, Health Protection Branch, Health and Welfare Department, Government of Canada, Ottawa, Canada

    P. Thibert

Authors
  1. A. A. F. Sima
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  2. A. C. Lorusso
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  3. P. Thibert
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Additional information

Supported by the Canadian Diabetes Association, The Juvenile Diabetes Research Foundation, The Dean's Fund, University of Toronto, and The Toronto General Hospital Foundation

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Sima, A.A.F., Lorusso, A.C. & Thibert, P. Distal symmetric polyneuropathy in the spontaneously diabetic BB-Wistar rat. Acta Neuropathol 58, 39–47 (1982). https://doi.org/10.1007/BF00692696

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  • DOI: https://doi.org/10.1007/BF00692696

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