Summary
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1.
A histochemical and fine structural study of the developing rat choroid plexus was made from 1–3 days before birth to the adult stage.
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2.
The maturation of the choroidal epithelium is associated with a loss of cytoplasmic glycogen, increasing surface area of the plasma membrane associated with the development of an apparent adenosine triphosphatase activity, and increasing numbers of mitochondria and prominence of the rough endoplasmic reticulum associated with increasing diaphorase and dehydrogenase activity. Following birth, thiamine pyrophosphatase and adenosine mono- and diphosphatase activity appear in the blood vessels. Structures associated with pinocytotic activity are most numerous in young rats.
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3.
It is suggested that the increased susceptibility of young rats to experimentally produced hydrocephalus is related to the potential of their choroid plexus for active transport.
Zusammenfassung
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1.
Die Entwicklung des Plexus choroideus in der Ratte vom 1.–3. Tag vor der Geburt bis zur Reife wurde mit histochemischen Methoden und mit dem Elektronen-Mikroskop untersucht.
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2.
Die Reifung des Plexus-Epithels ist verbunden mit dem Schwund des Glykogens im Cytoplasma, mit eine Zunahme der Oberfläche der Zellmembrane zusammen mit dem Erscheinen von Adenosine-Triphosphatase-Aktivität sowie mit einer Zunahme von Mitochondrien und von endoplasmischem Reticulum zusammen mit einer Zunahme der Diaphorase- und Dehydrogenase-Aktivität. Nach der Geburt kann die Aktivität von Thiamine-Pyrophosphatase und von Adenosine-Mono- und Di-Phosphatase in den Blutgefäßen nachgewiesen werden. Zellstrukturen, die pinocytotische Aktivität besitzen, sind in größter Anzahl in jungen Ratten vorhanden.
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3.
Es wird angenommen, daß die erhöhte Empfänglichkeit von jungen Ratten für experimentell erzeugten Hydrocephalus auf die besondere Fähigkeit von deren Plexus choroideus zu aktivem Transport zurückzuführen ist.
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This investigation was supported by Gran # 05257-02 of the U.S.P.H.S.
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Cancilla, P.A., Zimmerman, H.M. & Becker, N.H. A histochemical and fine structure study of the developing rat choroid plexus. Acta Neuropathol 6, 188–200 (1966). https://doi.org/10.1007/BF00686764
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DOI: https://doi.org/10.1007/BF00686764