Summary
Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are observed in some areas of the perivascular space. Matrix vesicles and matrix giant bodies with or without mineralized deposits are also present in those areas. Energy disperisve, X-ray microanalysis evidenced the presence of both calcium and phosphorus (probably hydroxyapatite) mineralized precipitates. Production of psammoma bodies in the perivascular area may indicate that matrix vesicles and matrix giant bodies are derived from degenerated cells, which then sequestrate hydroxyapatite crystals to form psammoma bodies.
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References
Anderson HC (1980) Calcification processes. Pathol Annu 15:45–75
Essbach H (1943) Psammoma-Kugelentstehung und Rückbildungsprozesse in Hirnhauttumoren. Die Meningiome. Erg Allg Pathol Anat 36:185–490
Globus JH (1937) Meningiomas. Arch Neurol Psychiatry 38:667–712
Johannessen JV, Sabrinho-Simoes M (1980) The origin and significance of thyroid psammoma bodies. Lab Invest 43:287–296
Kim KM (1976) Calcification of matrix vasciles in human aortic valve and aortic media. Fed Proc 35:156–162
Kubota T, Hirano A, Yamamoto S, Kajikawa K (1984) The fine structure of psammoma bodies in meningocytic whorls. J Neuropathol Exp Neurol 43:37–44
Kubota T, Sato K, Yamamoto S, Hirano A (1984) Ultrastructural study of the formation of psammoma bodies in fibroblastic meningioma. J Neurosurg 60:512–517
Long DM (1973) Vascular ultrastructure in human meningiomas and schwannomas. J Neurosurg 38:409–419
Lynn JA, Panopio IT, Martin JH, Shaw ML, Race GJ (1968) Ultrastructural evidence for astroglial histogenesis of the monstrocellular astrocytoma (so-called monstrocellular sarcoma of brain). Cancer 22:356–366
Morgan AJ (1980) Mineralized deposits in the thoracic aorta of aged rats: Ultrastructural and electron probe X-ray microanalysis study. Exp Gerontol 15:563–573
Napolitano L, Kyle R, Fisher ER (1964) Ultrastructure of meningiomas and the derivation and nature of their cellular components. Cancer 17:233–241
Olson JL, Penney DP, Averill KA (1977) Fine-structural studies of a human thyroid adenoma, with special reference to psammoma bodies. Human Pathol 8:103–111
Paegle RD (1969) Ultrastructure of calcium deposits in arteriosclerotic human aortas. J Ultrastruct Res 26:412–423
Tanimura A, McGregor GH, Anderson HC (1983) Matrix vesicles in atherosclerotic calcification. Proc Soc Exp Biol Med 172:173–177
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Kubota, T., Hirano, A., Sato, K. et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma. Acta Neuropathol 66, 163–166 (1985). https://doi.org/10.1007/BF00688693
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DOI: https://doi.org/10.1007/BF00688693