Summary
A clinico-pathological case report on a case of juvenile Parkinson's disease (JPD) with widespread Lewy bodies (LBs) in the brain is presented with comparative morphological studies on two demented cases of “classical” Parkinson's disease (CPD) with disease onset at an older age. The clinical and histological pictures of this JPD case were typical of Parkinson's disease, excepting numerous Lewy bodies in the cerebrum. There were no neurofibrillary change nor senile plaques throughout the CNS. The distribution and histochemical and ultrastructural characters of the histological lesions (i.e., LBs) in the JPD and the two CPD cases were investigated and compared. The comparison showed no qualitative but only quantitative differences between the two types of Parkinson's disease. The present study also revealed that in CPD cases significant numbers of LBs could be present in the cerebral cortex, amygdaloid and claustrum. These lesions can be in part responsible for dementia in CPD.
Similar content being viewed by others
References
Bethlem J, den Hartog Jager WA (1960) The incidence and characteristics of Lewy bodies in idiopathic paralysis agitans (Parkinson's disease). J Neurol Neurosurg Psychiatry 23:74–80
den Hartog Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry 23:283–290
Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease. J Neuropathol Exp Neurol 24:398–414
Hunt JR (1918) Primary atrophy of the pallidal system of the corpus striatum. A contribution to the nature and pathology of paralysis agitans. Arch Intern Med 22:647–691
Ikeda K, Ikeda S, Yoshimura T, Kato H, Namba M (1978) Idiopathic parkinsonism with Lewy-type inclusions in cerebral cortex. A case report. Acta Neuropathol (Berl) 41:165–168
Jellinger K (1968) Progressive Pallidumatrophie. J Neurol Sci 6:19–44
Kosaka K (1978) Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathol (Berl) 42:127–134
Kosaka K, Yoshimura M, Ikeda K, Budka H (1984) Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree — A new disease? Clin Neuropathol 3:185–192
Lima B, Neves G, Nora M (1987) Juvenile parkinsonism: clinical and metabolic characteristics. J Neurol Neurosurg Psychiatry 50:345–348
Morimura Y, Hirano A (1986) The fine structural observation of Lewy bodies in the nucleus basalis of Meynert. Neurol Med (Tokyo) 24:370–378
Murofushi K, Tanaka Y (1982) A neuropathological study of parkinson's syndrome. Annual report of the Research Committee of Degenerative CNS Diseases. The Ministry of Health and Welfare of Japan, Tokyo, pp 171–175
Narabayashi H, Yokochi M, Mizuka R (1981) Pathological verification of two cases of juvenile parkinsonism. Annual report of the Research Committee of Degenerative CNS Diseases. The Ministry of Health and Welfare of Japan, Tokyo, pp 154–158
Ohama E, Ikuta F (1976) Parkinson's disease. Distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol (Berl) 34:311–319
Okeda R, Kayano T, Funata N, Kojima T, Miki M, Iwama H (1982) An autopsy case of Parkinson's disease associated clinically with dementia terminating in akinetic mutism and pathologically with multiple Lewy's bodies in the cerebral cortex. Brain Nerve (Tokyo) 34:311–319
Oppenheimer DR (1984) Disease of the basal ganglia, cerebellum and motor neurons. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology, 4th edn. Arnold, London, pp 699–747
Ota Y, Miyoshi S, Ueda O, Mukai T, Maeda A (1958) Familial paralysis agitans juvenilis. A clinical, anatomical and genetic study. Folia Psychiatr Neurol Jpn 12:112–121
Tomonaga M, Yoshimira M (1982) Parkinson's disease — From a pathological standpoint. Autonomic Nervous System (Tokyo) 19:142–147
Yokochi M (1979) Juvenile Parkinson's disease. 1. Clinical aspects. Adv Neurol Sci (Tokyo) 23:1048–1059
Yoshimura N, Shouji M, Matsui T (1982) An autopsy case of Parkinson's disease manifesting hyperphagia and dysphagia followed by severe achalasia (disorder of motility) of the esophagus. Brain Nerve (Tokyo) 34:741–746
van Bogaert L (1930) Contribution clinique et anatomique a l'étude de la paralysis agitans juvenile primitive (Atrophie progressive du globe pale de Ramsay Hunt). Rev Neurol (Paris) 37:315–326
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoshimura, N., Yoshimura, I., Asada, M. et al. Juvenile Parkinson's disease with widespread Lewy bodies in the brain. Acta Neuropathol 77, 213–218 (1988). https://doi.org/10.1007/BF00687434
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00687434