Summary
Changes occurring in serotonin neurons during hyperthermia and hyperthermia-induced convulsions were examined by quantiative immunohistochemistry. A marked increase in serotonin immunoreactivity was observed at the rostral and intermediate levels of the neostriatum of mice kept at high temperatures with no convulsions, and a significant reduction in serotonin immunoreactivity was verified throughout the neostiatum of mice which had hyperthermia-induced seizures. These results suggest that serotonin neurons change significantly during thermal stress and seizures, and that regional analysis is essential for an understanding of the role of serotonin neurons.
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References
Blue ME, Molliver ME (1987) 6-Hydroxydopamine induces serotonergic axon sprouting in cerebral cortex of newborn rat. Dev Brain Res 32:255–269
Cowen T, Alafaci C, Crockard HA, Burnstock G (1986) 5-HT-containing nerves to major cerebral arteries of the gerbil originate in the superior cervical ganglia. Brain Res 384:51–59
De Simoni MG, Dal Toso G, Fodritto F, Sokola A, Algeri S (1987) Modulation of striatal dopamine metabolism by the activity of dorsal raphe serotonergic afferences. Brain Res 411:81–88
Hara K, Tohyama I, Kimura H, Fukuda H, Nakamura S, Kameyama M (1987) Reversible serotonergic neurotoxicity ofN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MTPT) in mouse striatum studied by neurochemical and immunohistochemical approaches. Brain Res 410:371–374
Harri M, Tirri R (1969) Brain monoamines in the temperature acclimation of mice. Acta Physiol Scand 75:631–635
Lin Li-Hsien, Pivorun EB (1986) Effects of intrahypothalamically administrated norepinephrine, serotonin and bombesin on thermoregulation in the deermouse (Peromyscus maniculatus). Brain Res 364:212–219
Mori S, Ueda S, Yamada H, Takino T, Sano Y (1985) Immunohistochemical demonstration of serotonin nerve fibers in the corpus striatum of the rat, cat and monkey. Anat Embryol 173:1–5
Mize RR, Payne MP (1987) The innervation density of serotonergic (5-HT) fibers varies in different subdivisions of the cat lateral geniculate nucleus complex. Neurosci Lett 82:133–139
Myers RD (1981) Serotonin and thermoregulation: old and new views. J Physiol (Paris) 77:505–513
Niewenhuys R (1985) Chemoarchitecture of brain. Springer, Berlin Heidelberg New York, pp 33–41
Sidman RL, Angevine JB, Pierce ET (1971) Atlas of the mouse brain and spinal cord. Harvard University Press, Cambridge, pp 7–98
Soghomonian JJ, Doucet G, Descarries L (1987) Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res 425:85–100
Takeuchi Y, Sano Y (1984) Serotonin nerve fibers in the primary visual cortex of the monkey, quantitative and immunoelectron microscopical analysis. Anat Embryol 169:1–8
Takeuchi Y, Kimura H, Sano Y (1982) Immunohistochemical demonstration of the distribution of serotonin neurons in the brain stem of the rat and cat. Cell Tissue Res 224:247–267
Takeuchi Y, Kimura H, Matsuura T, Yonezawa T, Sano Y (1983) Distribution of serotonergic neurons in the central nervus system: a peroxidase-antiperoxidase study with antiserotonin antibodies. J Histochem Cytochem 31:181–185
Takeuchi Y, Fujiwara K, Ishimura H, Yoshioka H, Sawada T (1988) Serotonin reduction in the mouse neostriatum during hyperthermia-induced convulsions studied by immunohistochemistry. Acta Neuropathol (Berl) 75:541–546
Widmann R, Sperk G (1986) Topographical distribution of amines and major amine metabolites in the rat striatum. Brain Res 367:244–249
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Takeuchi, Y., Fujiwara, K., Sato, N. et al. Further confirmation of serotonin reduction in the neostriatum during hyperthermia-induced convulsions: a quantitative immunohistochemical study. Acta Neuropathol 77, 254–257 (1989). https://doi.org/10.1007/BF00687576
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DOI: https://doi.org/10.1007/BF00687576