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Nerve growth factor receptor immunoreactivity in human benign peripheral nerve sheath tumor

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Summary

In situ expression of nerve growth factor (NGF) receptors in human dermal and plexiform neurofibroma, schwannoma and traumatic neuroma was examined by an immunohistochemical method using a monoclonal anti-human NGF receptor antibody. Immunoreactivity for the NGF receptor was observed on the principal cells of both neurofibroma and schwannoma. Immunostaining by the anti-S-100β protein antibody in adjacent sections suggested that the vast majority of NGF receptor-positive cells were also positive for S-100β protein. In traumatic neuroma, staining for the NGF receptor was more intense in the perineurium than in the endoneurial cells.

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Authors and Affiliations

  1. Division of Neurology, Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, 480-11, Aichi, Japan

    T. Yasuda, G. Sobue & T. Mitsuma

  2. Department of Neurology, Nagoya University, 466, Nagoya, Japan

    T. Yasuda & A. Takahashi

  3. Department of Pathology, Nagoya University, 466, Nagoya, Japan

    Y. Hashizume

Authors
  1. T. Yasuda
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  2. G. Sobue
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  3. T. Mitsuma
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  4. A. Takahashi
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  5. Y. Hashizume
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Additional information

Supported by grants from National Center of Neurology and Psychiatry (NCNP) of the Ministry of Health and Welfare of Japan, the Uehara-kinen Memorial Foundation in Japan, and the Japanese Intractable Disease Research Foundation

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Yasuda, T., Sobue, G., Mitsuma, T. et al. Nerve growth factor receptor immunoreactivity in human benign peripheral nerve sheath tumor. Acta Neuropathol 77, 591–598 (1989). https://doi.org/10.1007/BF00687886

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  • DOI: https://doi.org/10.1007/BF00687886

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