Summary
Angiotropic lymphoma can present as a vascular disease in the central nervous system. The patient described in this report had a sudden pain in the region of the right superficial peroneal nerve and a nerve biopsy showed tumoral cells in the lumen of most small blood vessels. This pathology, first described in the skin as malignant angioendotheliomatosis, can be compared with the occurrence of multiple emboli in the vasa nervorum. In recent cases, tumoral markers have evidenced a lymphomatous origin, generally of the B type.
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References
Abe S, Shimbo Y, Saito T, Kohno M, Nishiyama A, Kumanishi T (1988) An immunohistochemical study on “neoplastic angioendotheliosis”: demonstration of B lymphocyte markers in the neoplastic cells. Acta Neuropathol (Berl) 75:313–316
Beal MF, Fisher CM (1982) Neoplastic angioendotheliosis. J Neurol Sci 53:359–375
Dolman CL (1986) Immunohistochemistry of so-called “neoplastic angioendotheliosis”. Acta Neuropathol (Berl) 72:197–199
Fulling KH, Gersell DJ (1983) Neoplastic angioendotheliomatosis. Histologic, immunohistochemical and ultrastructural findings in two cases. Cancer 51:1107–1118
Gherardi R, Gaulard P, Prost C, Rocha D, Imbert M, Andre C, Rochant H, Farcet JP (1986) T cell lymphoma revealed by a peripheral neuropathy. A report of two cases with an immunohistologic study on lymph node and nerve biopsies. Cancer 58:2710–2716
Krieger C, Robitaille Y, Jothy S, Elleker G (1982) Intravascular malignant histiocytosis mimicking central nervous system vasculitis: an immunopathological diagnostic approach. Ann Neurol 12:489–492
Nukada H, Dyck PJ (1987) Acute ischemia causes. Axonal stasis, swelling, attenuation, secondary demyelination. Ann Neurol 22:311–318
Ojeda VJ, Spagnolo DV (1986) Neoplastic angioendotheliosis is, in fact, intravascular malignant lymphoma. Acta Neuropathol (Berl) 72:203
Sheibani K, Battifora H, Winberg CD, Burke JS, Ben-Ezra J, Ellinger GM, Quigley MJ, Fernandez BB, Morrow D, Rappaport H (1986) Further evidence that “malignant angioendotheliomatosis” is an angiotropic large-cell lymphoma. N Engl J Med 314:943–948
Sunohara N, Mukoyama M, Satoyoshi E (1984) Neoplastic angioendotheliosis of the central nervous system. J Neurol 231:14–19
Vital C, Vallat JM (1987) Ultrastructural study of the human diseased peripheral nerve, 2nd ed. Elservier, New York, pp 167–171
Wick MR, Scheithauer BW, Okazaki H, Thomas JE (1982) Cerebral angioendotheliomatosis. Arch Pathol Lab Med 106:342–346
Wick MR, Mills SE, Scheithauer BW, Cooper PH, Davitz MA, Parkinson K (1986) Reassessment of malignant angioendotheliosis. Evidence in favor of its reclassification as intravascular lymphomatosis. Am J Surg Pathol 10:112–123
Zuber M, Gherardi R, Imbert M, Gaulard P, Kuentz M, Poirier J (1987) Peripheral neuropathy with distal nerve infiltration revealing a diffuse pleiomorphic malignant lymphoma. J Neurol 235:61–62
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Vital, C., Heraud, A., Vital, A. et al. Acute mononeuropathy with angiotropic lymphoma. Acta Neuropathol 78, 105–107 (1989). https://doi.org/10.1007/BF00687410
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DOI: https://doi.org/10.1007/BF00687410