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Cytomembranous inclusions in the peripheral nerves in AIDS

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Summary

We report finding tubuloreticular inclusions (TRI) in the endothelial cells of endo- and epineurial vessels in the sural nerve of 11 patients with AIDS. Six patients had a painful peripheral neuropathy, one a non-painful sensory neuropathy, one an acute inflammatory demyelinating polyradiculoneuropathy and one a thalidomide-related neuropathy. Two patients had no clinical evidence of neuropathy. The TRI are not specific to one neuropathy and are unlikely to contribute to the pathogenesis of peripheral nerve syndromes in AIDS.

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Authors and Affiliations

  1. Department of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, Great Britain

    G. N. Fuller & J. M. Jacobs

  2. Department of Neurology, Charing Cross and Westminster Medical School, Westminster Hospital, 17 Page Street, SW1 2AP, London, Great Britain

    G. N. Fuller

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  1. G. N. Fuller
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  2. J. M. Jacobs
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Medical Research Council Research Training Fellow

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Fuller, G.N., Jacobs, J.M. Cytomembranous inclusions in the peripheral nerves in AIDS. Acta Neuropathol 79, 336–339 (1989). https://doi.org/10.1007/BF00294672

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  • DOI: https://doi.org/10.1007/BF00294672

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