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Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A

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Summary

This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 μg/ml LPS or lipd A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.

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Kato, M., Ohno, K., Takeshita, K. et al. Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A. Acta Neuropathol 82, 384–388 (1991). https://doi.org/10.1007/BF00296549

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  • DOI: https://doi.org/10.1007/BF00296549

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