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Deletions on the long arm of chromosome 17 in pilocytic astrocytoma

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Summary

Pilocytic astrocytomas are the most common astrocytic tumors of childhood and differ clinically and histopathologically from those astrocytomas that affect adults. Studies of adult astrocytic tumors have revealed allelic losses on chromosomes 10, 17p, 19q and alterations in the epidermal growth factor receptor (EGFR) gene. We have previously examined pilocytic astrocytomas for allelic losses on chromosomes 10 and 19q and for amplification of the EGFR gene, but did not detect genomic alterations at these loci. In the present study we assayed 20 pilocytic astrocytomas for loss of allelic heterozygosity of chromosome 17p, including one locus in the p53 tumor suppressor gene. In addition, because pilocytic astrocytomas frequently affect patients with neurofibromatosis type 1 (NF1) and the NF1 gene has been mapped to 17q11.2, we also examined multiple loci on the long arm of chromosome 17. Allelic loss was observed on chromosome 17 in four cases (three sporadic, one NF1); all lost portions of the long arm in chromosome 17, and one tumor lost the short arm as well. One tumor showed an interstitial delection on the long arm that included the region of the NF1 gene. These data suggest the presence of a tumor suppressor gene on 17q that is associated with pilocytic astrocytomas. A potentiel candidate for this gene is the NF1 tumor suppressor gene.

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Authors and Affiliations

  1. Molecular Neuro-Oncology Laboratory, Massachusetts General Hospital, 02129, Charlestown, MA, USA

    Andreas von Deimling, David N. Louis & Bernd R. Seizinger

  2. Neurosurgical Service, Massachusetts General Hospital, 02129, Charlestown, MA, USA

    Andreas von Deimling, David N. Louis & Bernd R. Seizinger

  3. Molecular Neurogenetics Laboratory, Massachusetts General Hospital, 02129, Charlestown, MA, USA

    Anil G. Menon

  4. Harvard Medical School, 02129, Charlestown, MA, USA

    Anil G. Menon

  5. Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, W-5300, Bonn 1, Germany

    Andreas von Deimling & Otmar D. Wiestler

  6. Department of Pathology (Neuropathology), Massachusetts General Hospital, 02114, Boston, MA, USA

    David N. Louis

  7. Harvard Medical School, 02114, Boston, MA, USA

    David N. Louis

  8. Department of Neurosurgery, University of Zürich, Raemistrasse 100, CH-8091, Zürich, Switzerland

    Klaus von Ammon

  9. Laboratory of Neuropathology, Department of Pathology, University of Zürich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland

    Iver Petersen & Otmar D. Wiestler

  10. Department of Neuropathology, Southampton General Hospital, UK

    David Ellison

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  1. Andreas von Deimling
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  2. David N. Louis
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  4. Klaus von Ammon
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  5. Iver Petersen
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  7. Otmar D. Wiestler
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  8. Bernd R. Seizinger
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Additional information

Supported by grant CD 455 from the American Cancer Society (BRS) and by a grant from the Preuss Foundation (to BRS). AvD is a postdoctoral fellow supported by the Deutsche Forschungsge-meinschaft; DNL is a recipient of NIH Public Health Service NRSA CA 09144

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von Deimling, A., Louis, D.N., Menon, A.G. et al. Deletions on the long arm of chromosome 17 in pilocytic astrocytoma. Acta Neuropathol 86, 81–85 (1993). https://doi.org/10.1007/BF00454903

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  • DOI: https://doi.org/10.1007/BF00454903

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