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White matter amyloid in Alzheimer's disease brain

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Abstract

Amyloid β-protein (Aβ) deposits in the white matter were investigated by the double immunohistochemical staining for Aβ and neuritic, glial or vascular components. Reactive astroglia and neurite abnormality were absent around Aβ deposits in the white matter (w-Aβ) even those with a core. The association of w-Aβ with blood vessels was not consistent. Aggregates of activated microglia were found to be the sole but a consistent accompaniment of Aβ deposits even in the absence of other components such as neuron, synapse, neurite abnormality and reactive astroglia, as observed in the white matter. This suggests that the aggregates of activated microglia most likely represent one of the factors promoting the process of Aβ deposition.

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Authors and Affiliations

  1. Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan

    Toshiki Uchihara

  2. Department of Neuropathology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo, Japan

    Toshiki Uchihara, Hiromi Kondo, Haruhiko Akiyama & Kenji Ikeda

  3. Laboratories R. Escourolle, Service de Neuropathologie, Groupe Hospitalier La Petié-La Salpêtrière, 47 Bd. de l'Hôpital, F-75651, Paris, CEDEX, France

    Toshiki Uchihara

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  1. Toshiki Uchihara
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  4. Kenji Ikeda
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Uchihara, T., Kondo, H., Akiyama, H. et al. White matter amyloid in Alzheimer's disease brain. Acta Neuropathol 90, 51–56 (1995). https://doi.org/10.1007/BF00294459

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  • DOI: https://doi.org/10.1007/BF00294459

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