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The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes

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Abstract

We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I (HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found HTLV-I in CD4+ cells but not in macrophages. This finding suggests that most of the HTLV-I-containing CD4+ cells are not macrophages but lymphocytes.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890, Japan Tel.: 81-99-275-5332; Fax: 81-99-265-7164; e-mail: ihiguchi@med6.kufm.kagoshima-u.ac.jp, , , , , , JP

    I. Higuchi, K. Hashimoto, E. Matsuoka, R. Rosales, M. Nakagawa, K. Arimura & M. Osame

  2. Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, , , , , , JP

    S. Izumo

Authors
  1. I. Higuchi
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  2. K. Hashimoto
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  3. E. Matsuoka
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  4. R. Rosales
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  5. M. Nakagawa
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  6. K. Arimura
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  7. S. Izumo
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  8. M. Osame
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Received: 12 February 1996 / Revised, accepted: 11 April 1996

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Higuchi, I., Hashimoto, K., Matsuoka, E. et al. The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes. Acta Neuropathol 92, 358–361 (1996). https://doi.org/10.1007/s004010050530

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  • DOI: https://doi.org/10.1007/s004010050530

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