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Cementsome, a new interpretation of the membrane-coating granule

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Summary

Small cytoplasmic granules, which have been found in various keratinizing epithelia and called the membrane-coating granules or keratinosomes, were found to be amenable to phospholipase C digestion. Granules discharged into the intercellular spaces could also be digested with phospholipase C. Since it is believed that phospholipids are part of the intercellular cement not only in the skin but in other tightly junctioned epithelia, the name “cement granule” or “cementsome” was proposed for these granules.

Zusammenfassung

Kleine protoplasmatische Körnchen, welche in verschiedenen verhornenden Epithelien gefunden worden sind und als der Zellmembran aufliegende Körnchen oder Keratinosome bezeichnet wurden, konnten durch Phospholipase C gespalten werden. Körnchen, die in die intercellulären Zwischenräume abgestoßen waren, waren gleichfalls durch Phospholipase C spaltbar. Da angenommen wird, daß Phosphatide einen Teil der intercellularen Kittsubstanz bilden, nicht nur in der Haut, sondern auch in anderen eng zusammengefügten Epithelien, wird die Bezeichnung „Kittkörnchen“ oder „Kittkörper“ für diese Körnchen vorgeschlagen.

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Authors and Affiliations

  1. Veterans Administration Hospital, Memphis, Tenn., USA

    K. Hashimoto

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  1. K. Hashimoto
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This work is partially supported by Part I Designated Research Grant and Medical Investigator Award of the Veterans Administration.

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Hashimoto, K. Cementsome, a new interpretation of the membrane-coating granule. Arch. Derm. Res. 240, 349–364 (1971). https://doi.org/10.1007/BF00584589

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  • DOI: https://doi.org/10.1007/BF00584589

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