Summary
Serum aminopeptidase A (AAP) activity was measured in normal pregnancy and pre-eclampsia. The AAP activity in normal pregnancy increased progressively with advancing gestation, reaching the highest value at the end of pregnancy. The AAP activity in pregnancy complicated by pre-eclampsia was lower than in normal pregnancy.
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References
Glenner GG, McMillian PJ, Folk JE (1962) A mammalian peptidase specific for the hydrolysis of N-terminal α-L-glutamyl and aspartyl residues. Nature 194:867
Khairallah PA, Page IH (1976) Plasma angiotensinases. Biochem Med 1:1–8
Klaus D (1962) Untersuchungen über die Angiotensinase im Serum Gesunder und Kranker. Klin Wochenschr 40:701–702
Lalu K, Lampelo S, Nummelin-Kortelainen M, Vanha-Pertlula T (1984) Purification and partial characterization of aminopeptidase A from the serum of pregnant and non-pregnant women. Biochim Biophys Acta 789:324–333
Landesmann R, Biron P, Castellanos R, Russa RL, Wilson KH (1963) Plasma angiotensinase activity in normal and toxemic pregnancy. Obstet Gynecol 22:316–323
Mizutani S, Yoshino M, Oya M (1976) A comparison of oxytocinase and L-methionine-insensitive leucine aminopeptidase during normal pregnancy. Clin Biochem 9:228
Mizutani S, Okano K, Hesegawa E, Sakura H, Yamada M. (1981) Aminopeptidase A in human placenta. Biochim Biophys Acta 678:168–170
Mizutani S, Akiyama H, Kurauchi O, Taira H, Narita O, Tomoda Y (1985a) Plasma angiotensin I and serum placental leucine aminopeptidase (P-LAP) in pre-eclampsia. Arch Gynecol 236:165–172
Mizutani S, Akiyama H, Kurauchi O, Taira H, Narita O, Tomoda Y (1985b) In-vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, Pregnancy sera and purified placental aminopeptidases. Acta Endocrinol 110:135–139
Nagatsu I, Gillespiel L, Folk JE, Glenner GG (1964) Serum aminopeptidases, “angiotensinase”, and hypertension-I. Biochem Pharmacol 14:721–728
Tapia HR, Johnson CE, Storong CG (1972) Renin-angiotensin system in normal and in hypertensive disease of pregnancy. Lancet II: 847–850
Vorherr H, Dimitrow A, Hüter J (1965) Biologische Untersuchungen über den Abbau Hypertensin durch Blutplasma von nichtschwangeren und schwangeren Frauen. Klin Wochenschr 43:614–617
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Mizutani, S., Yamada, R., Kurauchi, O. et al. Serum aminopeptidase A (AAP) in normal pregnancy and pregnancy complicated by pre-eclampsia. Arch. Gynecol. 240, 27–31 (1987). https://doi.org/10.1007/BF02134061
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DOI: https://doi.org/10.1007/BF02134061