Abstract
650 couples with idiopathic subfertility (mean duration: 5.7 year, range 2–21 years) were treated during 2870 cycles by three assisted conception methods (each involving mild ovarian stimulation): I timed intercourse (TI), II intrauterine insemination (IUI), III in vitro fertilization/embryo transfer (IVF/ET). Treatment started with TI in most cases and then changed to IUI after three to six cycles. Couples who failed to conceive were treated after another 3–9 cycles by IVF/ET. An overall cumulative pregnancy rate of 80.2% was reached after 18 treatment months. The pregnancy rates per treatment cycle were: TI 5.3%, IUI 6.9%, IVF/ET 15.8% (per oocyte retrieval)
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Berg, F.D., Seifert-Klauss, V., Lauritzen, C. et al. A three step protocol for the treatment of idiopathic subfertility. Arch Gynecol Obstet 255, 173–180 (1994). https://doi.org/10.1007/BF02335082
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DOI: https://doi.org/10.1007/BF02335082