Summary
In 1974, six patients with incapacitating unilateral Ménière's disease were given an empiric treatment with intratympanic gentamycin sulfate via the eustachian tube using a tubal catheter with a small side-branch. These patients then showed excellent results with relief from vertigo over a 13-year period. Since 1980, we have treated patients suffering from Ménière's disease with isosorbide. When patients could not be controlled with this therapy, isosorbide was given in addition to intratympanic gentamycin therapy using a tubal catheter. Of 75 patients with Ménière's disease who received gentamycin and isosorbide therapy, 41 patients could be evaluated by the classification for Ménière's disease proposed by the American Academy of Opthalmology and Otolaryngology (AAOO). Subsequent results showed that vertigo improved in 73% of the patients. According to the AAOO classification, 11 patients (27%) were group A, 16 patients (39%) were group B, and 4 patients (10%) were group C. Eleven patients were group D (27%) and experienced persistent vertigo despite treatment. Our experiences show that patients with severe Ménière's disease can be readily treated with intratympanic gentamycin therapy using a tubal catheter, even on an outpatient basis. This treatment is also a most effective treatment, as it allows the effects of isosorbide to be obtained with smaller doses of gentamycin sulfate.
Similar content being viewed by others
References
Alford BR (1972) Committee on hearing and equilibrium. Report of subcommittee on equilibrium and its measurement. Ménière's disease: criteria for diagnosis and evaluation of therapy for reporting. Am Acad Opthalmol Otolaryngol 76:1462–1464
Beck C, Schmidt CL (1978) 10 years of experience with intratympanally applied streptomycin (gentamycin) in the therapy of Morbus Ménière. Arch Otorhinolaryngol 221:149–152
Brodal A (1974) Anatomy of the vestibular nuclei and their connections. In: Kornhuber HH (ed) The vestibular system. Springer, Berlin Heidelberg New York (Handbook of sensory physiology, vol 6/1. pp 240–352)
Gacek RR (1974) Morphological aspects of the efferent vestibular system. In: Kornhuber HH (ed) The vestibular system. Springer, Berlin Heidelberg New York (Handbook of sensory physiology, vol 6/1. pp 213–219)
Gacek RR, Rasmussen GL (1961) Fiber analysis of the statoacoustic nerve of guinea pig, cat and monkey. Anat Rec 139:455–463
Hanson HV (1951) The treatment of endolymphatic hydrops (Ménière's disease) with streptomycin. Ann Otol Rhinol Laryngol 60:676–692
Schmidt CL, Beck C (1980) Behandlung des Morbus Ménière mit intratympanal appliziertem GentamycinSulfate. Laryngol Rhinol 59:804–807
Schuknecht HF (1957) Ablation therapy in the management of Ménière's disease. Acta Otolaryngol (Stockh) 132:1–42
Shimazu H (1968) Neuronal organization of the horizontal canal system in the vestibular nuclei. Adv Neurol Sci 12:316–324
Watanuki K (1971) The pathologic change in the vestibular epithelia due to gentamycin sulfate. Pract Otol (Kyoto) 64: 775–781
Wersäll J (1956) Studies on the structure and innervation of the sensory epithelium of the cristae ampullares in the guinea pig as revealed by an electron microscope. Acta Otolaryngol (Stockh) [Suppl] 126:1–85
Yamazaki T, Watanabe S, Kozaki H, Abe T (1975) Ménière's disease. J Sapporo City Gen Hosp 36:67–78
Yamazaki T, Watanabe S, Kozaki H, Abe T, Yamamoto K, Yanai T, Sakai N, Yamakawa M, Matsushima J (1980) Estimation of treatment of patients with Ménière's disease by questionnaires. Pract Otol (Kyoyo) 73:1134–1141
Yamazaki T, Hayashi N, Watanabe S, Kozaki H, Abe T (1981) Ménière's disease and isosorbide as an oral hyperosmotic agent-evaluation of therapeutic effects with clinical electrocochleography. Otologica (Fukuoka) 27:559–569
Yamazaki T, Imoto T, Hayashi N, Watanabe S, Kozaki H, Abe T (1982) Ménièrsche Krankheit und Isosorbid. Arch Otorhinolaryngol 234:97–104
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamazaki, T., Hayashi, M., Hayashi, N. et al. Intratympanic gentamycin therapy for Ménière's disease placed by tubal catheter with systemic isosorbide. Arch Otorhinolaryngol 245, 170–174 (1988). https://doi.org/10.1007/BF00464021
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00464021