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Kinin generation following methacholine nasal airway challenge of non-allergic subjects

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Summary

Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.

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Authors and Affiliations

  1. Department of Clinical Immunology and Asthma Clinic, Free University of Berlin, 1000 Berlin 65, Federal Republic of Germany

    C. R. Baumgarten, W. Niemz & G. Kunkel

Authors
  1. C. R. Baumgarten
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  2. W. Niemz
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  3. G. Kunkel
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Baumgarten, C.R., Niemz, W. & Kunkel, G. Kinin generation following methacholine nasal airway challenge of non-allergic subjects. Eur Arch Otorhinolaryngol 249, 318–321 (1992). https://doi.org/10.1007/BF00179380

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  • DOI: https://doi.org/10.1007/BF00179380

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