Abstract
Proton therapy offers potentially considerable advantages in the management of slow-growing, poorly resectable or non-resectable tumors resistant to x-rays and located close to critical radiosensitive anatomical structures, such as the brain stem of the spinal cord. Among over 13 000 irradiated patients in the USA, Europe, and Japan, two major clinical indications have been documented: 1. The conservative management of choroidal melanomas, in which 98% 5-year local control can be expected at the price of low toxicity and visual preservation in approximately half of them. 2. The curative management of low-grade chondrosarcomas and chordomas of the base of the skull and cervical spine, leading to, in combination with maximal tumor resection, 84%–94% long-term survival. Other ongoing studies concern prostate, head and neck carcinomas as well as various intracranial tumors. Radiosurgical programs are being conducted generally with single fractions and under stereotactic conditions.
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Austin-Seymour M, Munzenrider JE, Lingood R, Goiten M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, Crowel C (1990) Fractionated proton radiation therapy of cranial and intra cranial tumors. Am J Clin Oncol 13:326–330
Duttenhaver JR, Shipley WU, Perrone T, Verhey LJ, Goiten M, Munzenrider JE, Prout GR, Parkhust EC, Suit HD (1983) Protons and megavoltage x-rays as boost therapy for patients irradiated for localized prostatic carcinoma. An early phase 1/11 comparison. Cancer 51:1599–1604
Kjellberg RN, Abe M (1988) Sterotactic Bragg peak proton beam therapy. In: Lunsford LD (ed) Modern stereotactic neurosurgery, pp 463–470
Munzenrider JE, Gragoudas ES, Seddon VM, Sisterson J, McNulty P, Birnbaum S, Johnson K, Austin-Seymour M, Slater J, Goiten MM, Verhey JL, Uric M, Ruotolo DM, Egan K, Osuna F (1988) Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. Int J Radiat Oncol Biol Phys 15:553–558
Munzenrider JE, Verhey LJ, Gragoudas ES, Seddon VM, Urie M, Gentry R, Birnbaum S, Ruotolo DM, Crowell C, MacManus P, Finn S, Sisterson J, Johnson K, Egan K, Lento D, Bassin P (1989) Conservative treatment of uveal melanoma: local recurrence after proton beam therapy. Int J Radiat Oncol Biol Phys 17:493–498
Proceedings, Annual meeting: Proton Therapy Cooperation Group PTCOG XIV (May 1991), Cambridge, USA
Proceedings, Annual meeting: Proton Therapy Cooperation Group PTCOG XVII (November 1992) Loma Linda, USA
Shipley WU, Tepper JE, Prout SR, Verhey LJ, Mendiondo OA, Goiten MM, Koehler AM, Suit HD (1979) Proton radiation as boost therapy for localized prostatic carcinoma. JAMA 241:1912–1915
Tsujii H, Tsuji H, Inada T, Maruhashi A, Hayakawa Y, Takada Y, Tada J, Fukumoto S, Tatuzaki H, Ohara K, Kitagawa T (1993) Clinical results of fractionated proton therapy. Int J Radiat On-col Biol Phys 25:49–60
Urie M, Fullerton B, Tatsuzaki H, Birnbaum S, Suit HD, Convery K, Skates S, Goiten M (1992) A close response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. Int J Radiat Oncol Biol Phys 23:27–39
Wilson RR (1946) Radiological use of fast protons. Radiology 47:487–491
Zimmerman LE, McLean IW, Foster WD (1978) Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells? Br J Ophthalmol 62:420–425
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Habrand, J.L., Schlienger, P., Schwartz, L. et al. Clinical applications of proton therapy. Radiat Environ Biophys 34, 41–44 (1995). https://doi.org/10.1007/BF01210544
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DOI: https://doi.org/10.1007/BF01210544