Summary
Experiments with 73 GrCh rabbits showed, that both homologous and heterologous (bovine) photoreceptor outer segments (ROS) induce chorioretinitic diseases of the same kind. The findings refer to questions of localization and efficiency of homologous and heterologous (bovine) pathogenic ROS antigens.
Zusammenfassung
Durch Versuche an 73 GrCh-Kaninchen wird belegt, daß homologe und heterologe (bovine) Photoreceptor-Außensegmente (ROS) klinisch gleichartige Chorioretinitiden induzieren. Die Befunde vermitteln Hinweise zur Lokalisation und zum Wirkungsgrad des homologen und heterologen (bovinen) pathogenen Antigens.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Aronson, S. B.: Experimental allergic uveitis. Uveitis following immunization to homologous and heterologous uveal and retinovitreous preparations. Arch. Ophthal. (Chic.) 80, 235–242 (1968)
Faure, J.-P., de Kozak, Y., Dorey, C., Torres, R.: Production of retino-uveitis in guinea pigs by immunization with outer segments of heterologous photoreceptor cells. Biomedicine Express 19, 403–407 (1973)
Faure, J.-P., Torres, R., de Kozak, Y., Bloch-Michel, E.: Lésions chorio-rétiniennes expérimentales chez le cobaye par immunisation contre l'antigène rétinien. Bull. Soc. franç. Ophtal. 85 (1872)
Hempel, E., Tilgner, S., Sych, F.-J., Meyer, W., Schröder, K.-D.: Experimentelle Homoimmunuveitis (Chorioretinitis) durch Photorezeptoraußensegmente. Klin. Mbl. Augenheilk. 165, 630–632 (1974)
Kalsow, C. M., Wacker, W. B.: Localization of a uveitogenic soluble retinal antigen in the normal guinea pig eye by an indirect fluorescent antibody technique. Int. Arch. Allergy 44, 11–20 (1973)
Lerner II, E. M., Stone, S. H., Meyers, R. E., von Sallmann, L.: Autoimmune chorioretinitis in rhesus monkeys. Science 162, 561–562 (1968)
Macdonald, R., Jr.: Correlative studies on experimental allergic uveo-retinal disease. Trans. Amer. ophthal. Soc. 69, 397–439 (1971)
Rahi, A. H.: Autoimmunity and the retina. I. Antigenic specificity of photoreceptor cells. Brit. J. Ophthal. 54, 441–444 (1970)
von Sallmann, L., Meyers, R. E., Stone, S. H., Lerner II, E. M.: Retinal and uveal inflammation in monkeys following inoculation with homologous retinal antigen. Arch. Ophthal. (Chic.) 81, 374–382 (1969)
Schröder, K.-D., Meyer, W., Hempel, E., Tilgner, S.: Experimentell allergische Chorioretinitis bei Kaninchen durch Immunisierung mit homologer Retina in Adjuvans. I. Klinische Untersuchungen. Albrecht v. Graefes Arch. klin. exp. Ophthal. 191, 239–246 (1974)
Tilgner, S., Hempel, E., Meyer, W., Schröder, K.-D.: Experimentell allergische Chorioretinitis bei Kaninchen durch Immunisierung mit homologer Retina in Adjuvans. II. Histologische Untersuchungen. Albrecht v. Graefes Arch. klin. exp. Ophthal. 191, 285–298 (1974)
Tilgner, S., Meyer, W., Hempel, E., Schröder, K.-D.: Experimental allergic chorioretinitis in rabbits following immunization to homologous retina. Exp. Eye Res. 15, 71–73 (1973)
Wacker, W. B.: Experimental allergic uveitis. Studies on characterization and isolation of the pathogenic retina antigen. Int. Arch. Allergy 45, 639–656 (1973)
Wacker, W. B., Barbee, J., Macdonald, R., Jr.: Experimental allergic uveitis. III. Manifestations produced in the guinea pig by immunization with homologous retina. Invest. Ophthal. 8, 381–392 (1969)
Wacker, W. B., Kalsow, C. M.: Autoimmune uveo-retinitis in the rat sensitized with retina photoreceptor cell antigen. Int. Arch. Allergy 45, 582–592 (1973)
Wacker, W. B., Lipton, M. M.: Experimental allergic uveitis. Homologous retina as uveitogenic antigen. Nature (Lond.) 206, 253–254 [1965)
Wacker, W. B., Lipton, M. M.: Experimental allergic uveitis. I. Production in the guinea pig and rabbit by immunization with retina in adjuvant. J. Immunol. 101, 151–156 (1968a)
Wacker, W. B., Lipton, M. M.: Experimental allergic uveitis. II. Serologic and hypersensitive responses of the guinea pig following immunization with homologous retina. J. Immunol. 101, 157–165 (1968b)
Wacker, W. B., Lipton, M. M.: The role of two retina antigens in production of experimental allergic uveitis and its suppression by mycobacteria. Int. Arch. Allergy 41, 370–380 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tilgner, S., Hempel, E., Sych, F.J. et al. Experimentelle Chorioretinitis des Kaninchens durch homologe und heterologe Photoreceptor-Außensegmente. Albrecht von Graefes Arch. Klin. Ophthalmol. 197, 269–272 (1975). https://doi.org/10.1007/BF00410871
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00410871