Summary
Studies to detect disorders of pulmonary function were performed on 42 workers at a poultry farm. All the subjects were exposed to organic dusts and sensitised to poultry antigens. Typical signs of bird fancier's lung were recorded in two of them.
Included in all examinations were immunological diagnosis by means of counter-immunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms.
Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body box plethysmography, oesophago-balloon technique), respiratory mechanics of the small airways (closing volume), distributional analysis, diffusion analysis, and blood gas analysis.
A disorder of pulmonary function was recordable in 40 sensitised individuals. Such disorder being characterised by obstruction of the larger airways and slight inhomogeneity. The small airways were not narrowed. No restriction nor disturbed diffusion were established. The severity of obstruction was found to be related to the degree of sensitisation.
The following more clearly pronounced changes in terms of functional diagnosis were recordable from two poultry workers with allergic alveolitis: obstruction of larger airways with concomitant restriction, marked inhomogeneity, and disorder of diffusion.
The disorders, relatively discrete, led to mild PO2-reduction in sensitised individuals, whereas mild hypoxaemia was recorded from subjects with allergic alveolitis.
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References
Anthoniesen, N. R.: Report on information-session on ‚closing volume’ determination. Atlantic City 1972
Bergmann, K.-Chr., Luther, P., Kramer, H., Petro, W.: Diagnostische und pathogenetische Probleme bei verschiedenen Sensibilisierungsformen durch inhalierte organische Stäube. II. Internationaler Kongreß der Aerosole in der Medizin, Warschau 1977
Bütikofer, E., Rohner, R., Scherrer, M.: Farmerlunge in der Schweiz. Schweiz. Med. Wochenschr. 99, 793–800 (1969)
Fink, J. N., Sosmann, A. J., Barboniak, J., Schlueter, D. P., Holmes, R. A.: Pigeon breeder's disease. Ann. Intern. Med. 68, 1205–1219 (1968)
Hapke, E. J., Seal, R. M. E., Thomas, G. O., Hayes, M., Meek, J. C.: Farmer's lung. Thorax 23, 451–468 (1968)
Hargraeve, F. E., Pepys, J., Longbottom, J. L., Wraith, D. G.: Bird breeder's (fancier's) lung. Lancet 1, 445–449 (1966)
Hoehne, J. H., Reed, C. E., Dickie, H. A.: Allergic bronchopulmonary aspergillosis is not rare. Chest 4, 177–181 (1973)
Jackson, E., Welch, K. M. A.: Mushroom workers lung. Thorax 25, 25–30 (1970)
Jäger, L.: Sollwerte der Ventilation. Z. Tuberk. 125, 345–354 (1966)
Krogh, A., Krogh, M.: On the rate of diffusion of carbonic oxide into the lungs of man. Scand. Arch. Physiol. 27, 236–247 (1910)
McGrath, M. W., Thomson, M. L.: The effect of age. body size and lung volume change on alveolar-capillary permeability and diffusing capacity in man. J. Physiol. (Lond.) 146, 572–583 (1959)
Mittman, Ch., Edelman, N. H., Norris, A. H., Shock, N. W.: Relationship between chest wall and pulmonary compliance and age. J. Appl. Physiol. 20, 1211–1216 (1965)
Morgan, D. C., Smyth, J. T., Lister, R. W., Pethybridge, R. J.: Chest symptoms and farmer's lung: a community survey, Br. J. Ind. Med. 30, 259–265 (1973)
Müller, E., Wuthe, H., Petro, W., Vogel, J.: Referenzwerte für die Distributionsanalyse mit einfachen atemmechanischen Inhomogenitätsmassen. Dtsch. Gesundh: Wes. 32, 549–554 (1977)
Müller, E., Petro, W., Wuthe, H., Vogel, J.: Referenzwerte respiratorischer Funktionsparameter bei Erwachsenen. 4. Mitteilung: Referenzwerte für atemmechanische Vorfeldparameter. Dtsch. Gesundh.-Wes. (in press)
Noster, U., Hansen, B. M., Felten, G., Schulz, K. H.: Pilzzüchterlunge durch Speisepilzsporen. Dtsch. Med. Wochenschr. 101, 1241–1245 (1976)
Pasquis, P., Denis, Ph., Hellot, M. F., Lefrancois, R.: Compliance pulmonaire dynamique. Valeurs de reference. Bull Europ. Physiopath. Resp. 12, 559–668 (1976)
Pepys, J.: Pulmonary Hypersensitivity disease due to inhaled organic antigens. Postgrad. bled. J. 42, 698–702 (1966)
Petro, W., Harzendorf, E., Wuthe, H., Lachmann, B., Vogel, J.: Pulmonale Diffusionsanalysemittels einer eigenen Geräteeinheit und einem Computerprogramm zur schnellen Bestimmung der Gesamtdiffusion und ihrer Eirizelkomponenten. Z. Erkr. Atmungsorgane 140, 231–241 (1974)
Petro, W., Bergmann, K.-Chr., Zochert, I., Vogel, J.: Pulmonale Funk tionseinsehränkungen bei allergischer Alveolitis. Dtsch. Gesundh.-Wes. 31, 1758–1762 (1976)
Petro, W., Vogel, J. et al.: Referenzwerte respiratorischer Funktionsparameter bei Erwachsenen. 1. Mitteilung: Referenzwerte der arteriellen O2-Spannung bei Erwachsenen — Gemeinschaftsarbeit der AG Pathophystologie der Atmung. Dtsch. Gesundh,-Wes.32, 38–44 (1977)
Petro, W., Müller, E., Wuthe, H., Bergmann, K.-Ch., Vogel, J.: Changes of lung mechanics in allergic alveolitis. Bull. Europ. Physiopath. Resp.13, 58–60 (1977)
Riley, D. J., Saldana, M.: Pigeon breeder's lung. Am. Rev. Respir. Dis.107, 456–460 (1973)
Roughton, F. J. W., Forster, R. E.: The importance of diffusion and chemical reactions in determining rate of change of gases in the human lung, with special references to true diffusing capacity of pulmonary membrane and volume of blood in lung capillaries. J. Appl. Physiol.11, 290–302 (1957)
Scherrer, M.: Lunge nfunktionsprüfyngen bei diffusen interstitiellen Lungenerkrankungen. Schweiz. Med. Wochenschr.100, 1829–1835 (1970)
Schofield, N. M., Davies, R. J., Cameron, J. R., Green, M.: Small airways in fibrosing alveolitis. Am. Rev. Respir. Dis.113, 729–735 (1976)
Siggaard-Anderson, O., Engel, K.: A new acid-base nomogram. Scand. J. Clin. Lab. Invest.12, 177–186 (1960)
Smyth, J. T., Adkins, G. E., Lloyd, M., Moore, B. McWhite, E.: Farmer's lung in Devon. Thorax 30, 197–203 (1975)
Wichert, P. v.: Diagnostik allergischer und fibrosierender Alveolitiden und Lungenfibrosen. Dtsch. Med. Wochenschr.97, 383–385 (1972)
Wuthe, H., Petro, W., Müller, E., Merker, G., Vogel, J.: Bestimmung von Referenzwerten der Closing-Volume-Technik zur Früherfassung der Luftwegsobstruktion unter epidemiotogischen Bedingungen. Dtsch. Gesundh.-Wes.31, 2036–2041 (1976)
Wuthe, H., Petro, W., Vogel, J.: Die ‚Closing-Volume’Bestimmung unter Verwendung der PO2-Mikromeßkammer als Gasanalysator. Dtsch. Gesundh:-Wes.32, 323–324 (1977)
Wuthe, H., Müller, E. et al.: Referenzwerte respiratorischer Funktionsparameter bei Erwachsenen: 3. Mitteilung: Referenzwerte body plethysmographischer Parameter: Dtsch. Gesundh: Wes.32, 1844–1850 (1977)
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Petro, W., Bergmann, K.C., Heinze, R. et al. Long-term occupational inhalation of organic dust — Effect on pulmonary function. Int. Arch Occup Environ Heath 42, 119–127 (1978). https://doi.org/10.1007/BF01297550
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DOI: https://doi.org/10.1007/BF01297550