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Electrophysiological study of nerve injuries in workers handling acrylamide

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Summary

Neurological and electrophysiological examination of 15 workers handling acrylamide in a factory revealed abnormal signs of peripheral nerve functions in all cases. Neurological abnormalities were: absent deep reflexes, decreased superficial sense and suppressed vibration sense. Action potentials in median nerve and tibial nerve were greatly reduced while conduction velocity was not greatly affected. Long-experienced workers had various complaints with ataxic gait and showed abnormal EEG.

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References

  • Auld, R. B., Bedwell, S. F.: Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide. Canad. med. Ass. J. 96, 652–654 (1967).

    Google Scholar 

  • Fujita, A., Shibata, M., Kato, H., Aomi, Y., Ito, K., Suzuki, K., Nakazawa, T., Takahashi, T.: Clinical observations of three cases of acrylamide poisoning. Nihon Iji Shimpo (Jap. med. J.) No 1869, 37–40 (1960).

    Google Scholar 

  • Fukao, R.: Electrophysiological studies on peripheral nerve; revaluation of M wave in evoked electromyogram. J. Jap. Soc. intern. Med. 58, 593–604 (1969).

    Google Scholar 

  • Fullerton, P. M.: Electrophysiological and histological observations on peripheral nerves in acrylamide poisoning in man. J. Neurol. Neurosurg. Psychiat. 32, 186–192 (1969).

    Google Scholar 

  • —, Barnes, J. M.: Peripheral neuropathy in rats produced by acrylamide. Brit. J. industr. Med. 23, 210–221 (1966).

    Google Scholar 

  • Garland, T. O., Patterson, M. W. H.: Six cases of acrylamide poisoning. Brit. med. J. 21, 134–138 (1967).

    Google Scholar 

  • Hamblin, D. O.: The toxicity of acrylamide, a preliminary report, Hommage Au Doyen Rene Fabre, 195–199 (1956).

  • Hashimoto, K., Aldridge, W. N.: Biochemical studies on acrylamide, a neurotoxic agent. Biochem. Pharmacol. 19, 2591–2604 (1970).

    Google Scholar 

  • Hodes, R., Larrabee, M. G., German, W.: Human electromyogram in response to nerve stimulation and the conduction velocity of motor axons. Arch. Neurol. Psychiat. (Chic.) 60, 340–365 (1948).

    Google Scholar 

  • Hopkins, A. P., Gilliat, R. W.: Acrylamide poisoning. Brit. med. J. 417, 18 Nov. (1967).

  • Kuperman, A. S.: Effects of acrylamide on the central nervous system of the cat. J. Pharmacol. exp. Ther. 123, 180–192 (1958).

    Google Scholar 

  • Leswing, A. P., Ribelin, W. E.: Physiologic and pathologic changes in acrylamide neuropathy. Arch. environma. Hlth. 18, 22–29 (1969).

    Google Scholar 

  • McCollister, D. D., Oyen, F., Rowe, V. K.: Toxicologie investigation of polyacryl-amides. Toxicol. appl. Pharmacol. 7, 639–651 (1965).

    Google Scholar 

  • Pleasure, D. E., Mishler, K. C., Engel, W. K.: Axonal transport of proteins in experimental neuropathies. Science 166, 524–525 (1969).

    Google Scholar 

  • Prineas, J.: The pathogenesis of dying-back polyneuropathies. Part II. An ultrastructural study of experimental acrylamide intoxication in the cat. J. Neuropath. exp. Neurol. 28, 598–621 (1969).

    Google Scholar 

  • Takahashi, M., Ohara, T.: Electrophysiology of peripheral nervous diseases. Clin. Electroenceph. 12, 393–400 (1970).

    Google Scholar 

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Takahashi, M., Ohara, T. & Hashimoto, K. Electrophysiological study of nerve injuries in workers handling acrylamide. Int. Arch. Arbeitsmed 28, 1–11 (1971). https://doi.org/10.1007/BF00539725

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  • DOI: https://doi.org/10.1007/BF00539725

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