Summary
The use of a 4 to 1 mixture of helium and oxygen in maximal work does not increase the capacity for transporting oxygen nor greatly modify the heart rate. It does favor the elimination of carbon dioxide. It is associated with the same increase in lactic acid but at the same time it favors the elimination of carbon dioxide; accordingly the change in pH is smaller.
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Dill, D.B., Edwards, H.T. & McFarland, R.A. Respiratory responses to changes in air density. Arbeitsphysiologie 9, 341–344 (1936). https://doi.org/10.1007/BF02009944
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DOI: https://doi.org/10.1007/BF02009944