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31P kernspinspektroskopie der magenwand nach proximaler selektiver vagotomie

31P-nuclear magnetic resonance (NMR) spectroscopy of the gastric wall after proximal selective vagotomy

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Summary

The phosphate metabolism of the gastric wall after proximal selective vagotomy (PSV) was investigated by means of 31P-NMR spectroscopy. The destruction of metabolism has been found just after PSV resulting in a significant decrease of adenosine diphosphates and adenosine triphosphates. 4 and 7 days after PSV the progress of metabolism regeneration was detected, nevertheless with the retardation of high energy phosphates ischemic degradation. The results indicate not only a hydrochloric acid activity reduction but diminution of gastric mucosa protective factors, too. In experimental gastric ulcers no energy phosphates have been found suggesting a mucosa cells necrobiosis.

Zusammenfassung

Im Experiment wurde der Einfluß der SPV auf den Phosphatmetabolismus der Magenwand bei Ratten mittels 31P-NMR Spektroskopie untersucht. Die SPV bewirkt unmittelbar nach der Operation eine Destruktion des Stoffwechsels der Magenwandzellen. Vier Tage nch der SPV kommt es zur Regeneration des Metabolismus. Eine Woche nach der Operation ist die funktionelle Zellregeneration abgeschlossen, der Stoffwechsel aber verlangsamt. Dies hat eine reduzierte Produktion von S`aure und Schutzfaktoren der Magenschleimhaut zur Folge. Experimentelle Läasionen der Magenschleimhaut durch Phenylbutazon bewirken ebenso eine Zerstörung des Stoffwechsels der Magenwandzellen bis zum kompletten Zelluntergang.

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Authors and Affiliations

  1. Chirurgische Klinik, Institut für Ärztliche Fortbildung, Bratislava, Limbova 12, Czechoslovakia

    J. Danis &  J. Cerny

  2. Labor der NMR Spektroskopie, Chemische Fakultät Slowakische Technische Hochschule, Bratislava, Janska 5, Czechoslovakia

    I. Goljer & L. Zalibera

  3. Institut für Biochemie, Medizinische Fakultät der Universität zu Köln, Joseph-Stelzmann-Straße 52, D-5000, Köln 41

    B. Tunggal

  4. Klinik und Poliklinik für Chirurgie, Allgemeine, Abdominal-, Thorax- und Gefäßchirurgie, Joseph-Stelzmann-StraBe 9, D-5000, Köln 41

    U. J. Hesse

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  1. J. Danis
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  2. I. Goljer
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  3. L. Zalibera
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  4. B. Tunggal
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  5. U. J. Hesse
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  6. J. Cerny
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Danis, J., Goljer, I., Zalibera, L. et al. 31P kernspinspektroskopie der magenwand nach proximaler selektiver vagotomie. Langenbecks Arch Chir 375, 205–207 (1990). https://doi.org/10.1007/BF00187439

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  • DOI: https://doi.org/10.1007/BF00187439

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