Summary
After curative resection of stomach carcinomas (adenocarcinomas: n=58, signet ring cell carcinomas: n = 24, undifferentiated carcinomas: n = 21) the DNA content of the tumor cells was compared with the histomorphological parameters. There was a correlation between the DNA content and the histomorphological parameters. The DNA analysis had no additionally prognostic influence. In the multivariate regression analysis the prognosis depended on lymph node status (p=0.0009), pT-stage (p = 0.02), tumor localization (p = 0.03) and the histological type (p=0.05). The prognosis was independent of the DNA content. Furthermore, neither did the degree of differentiation, the operative procedure, the safety distance, the size of the tumor, the sex nor the age of the patient have any influence on the prognosis.
Zusammenfassung
Am Tumormaterial von 103 Patienten nach kurativer Resektion wegen eines Magenkarzinoms wurde ein Vergleich des DNS-Gehaltes der Tumorzellen mit den histomorphologischen Parametern vorgenommen. Es zeigte sich, daß der DNS-Gehalt mit den histomorphologischen Parametern korreliert, ohne jedoch eine weitere prognostische Aussage zu ermöglichen. In der multivariaten Regressionsanalyse zur Beurteilung der prognostisch unabhängigen Variablen war demzufolge die rezidivfreie Überlebenszeit allein von der Infiltrationstiefe des Tumors und dem Lymphknotenstatus abhängig. Keinen Einfluß auf die rezidivfreie Überlebenszeit hatten der histologische Tumortyp, die Tumorlokalisation, das Operationsverfahren und der DNS-Gehalt.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Ballantyne KC, James PD, Robins RA, Baldwin RW, Hardcastle JD (1987) Flow cytometric analysis of the DNA content of gastric cancer. Br J Cancer 56: 52–54
Baba H, Korenaga D, Okamura T, Saito A, Watanabe A, Sugimachi K (1989) Prognostic significance of DNA content with special reference to age in gastric cancer. Cancer 63:1768–1772
Böttger Th, Storkel S, Stöckle M, Wahl W, Jugenheimer M, Effenberger-Kim Oh, Vinh T, Junginger Th (1991) DNA image cytometry-a prognostic tool in squamous cell carcinoma of the esophagus. Cancer 67:2290–2294
Böttger Th, Storkel S, Stöckle M, Gerber G, Junginger Th (1991) Bildanalytische DNS-Cytometrie - Eine Möglichkeit zur Beurteilung der Prognose nach Resektion von ductalen Pankreascarcinomen? Chirurg 62:725–731
Böttger Th, Gabbert H, Stöckle M, Hills M, Heintz A, Lang E, Junginger Th (1991) DNA image cytometry — a prognostic tool in rectum cancer? Dis Colon Rectum (eingereicht)
Czerniak B, Herz F, Koss LG (1987) DNA distribution patterns in early gastric carcinomas. Cancer 59:113–117
Haraguchi M, Okamura T, Korenaga D, Tsujitani S, Marin P, Sugimachi K (1987) Heterogeneity of DNA ploidy in patients with undifferentiated carcinomas of the stomach. Cancer 59:922–924
Hattori T, Hosokawa Y, Fukuda M, Sugihara H, Hamada S, Takamatsu T, Nakanishi K, Tsuchihashi Y, Kitamura T, Fujita S (1984) Analysis of DNA ploidy patterns of gastric carcinomas of Japanese. Cancer 54:1591–1597
Inokuchi K, Kodama Y, Sasaki O, Kamegawa T, Okamura T (1983) Differentiation of growth patterns of early gastric car-cinoma determined by cytophotometric DNA analysis. Cancer 51:1138–1141
Japanese Research Society for Gastric Cancer (1985) Allgemeine Richtlinien für Chirurgie und Pathologie der japanischen Magencarcinomstudie. Chirurg 56:539
Korenaga D, Mori M, Okamura T, Sugimachi K, Enjoji M (1986) DNA ploidy in clinical malignant gastric lesions less than 5 mm in diameter. Cancer 58:2542–2545
Korenaga D, Okamura T, Saito A, Baba H, Sugimachi K (1988) DNA ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer. Cancer 62: 309–313
Korenaga D, Haraguchi M, Okamura T Baba H, Saito A, Sugimachi K (1989) DNA ploidy and tumor invasion in human gastric cancer. Arch Surg 124:314–318
MaCartney J, Camplejohn R, Powell G (1986) DNA flow cytometry of histological material form human gastric cancer. J Pathol 148:273–277
Ohyama S, Yonemura, Y, Miyazaki I (1990) Prognostic value of S-phase fraction and DNA ploidy studied with in vivo administration of bromodeoxyuridine on human gastric cancers. Cancer 65:116–121
Sasaki K, Hashimoto T Kawachino K, Takahashi M (1988) Intratumoral regional differences in DNA ploidy of gastrointestinal carcinomas. Cancer 62:2569–2575
Schlag P, Buhl K, Schwarz V, Möller P, Herfarth Ch (1989) Die neue TNM-Klassifikation und ihre Auswirkung auf die chirurgische Behandlung des Magencarcinoms. Chirurg 60:8–15
Sowa M, Yoshino H, Kato Y, Nishimura M, Kamino K, Umeyama K (1988) An analysis of the DNA ploidy patterns of gastric cancer. Cancer 62:1325–1330
Sugihara H, Hattori T Fukuda M, Fujita S (1987) Cell proliferation and differentiation in intramucosal and advanced signet ring cell carcinomas of the human stomach. Virchows Arch [A] 411:117–127
Sugihara H, Hattori T Fujita S, Hirose K, Fukuda M (1990) Regional ploidy variations in signet ring cell carcinomas of the stomach. Cancer 65:122–129
Yonemura Y, Sugiyama K, Fujimura T, De Aretxabala X, Kamata T Kosaka T, Yamaguchi A, Miwa K, Miyazaki I (1988) Correlation of DNA ploidy and proliferative activity in human gastric cancer. Cancer 62:1497–1502
Schillaci A, Tirindelli DD, Ferri M, Teodori L, Mauro F, Nicolanti V, Stipa S (1990) Flow cytometric analysis in colorectal carcinoma: prognostic significance of cellular DNA content. Int J Colorect Dis 5:223–227
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Böttger, T., Gabbert, H., Stöckle, M. et al. Vergleich der DNS-Analyse mit histomorphologischen parametern beim Magenkarzinom. Langenbecks Arch Chir 377, 4–8 (1992). https://doi.org/10.1007/BF00186141
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00186141