Summary
The histologic, immunohistochemical and ultrastructural characteristics of two granular cell tumors arising from the right recurrent laryngeal and left facial nerves are described. S-100 protein was detected both in the nuclei and cytoplasm of the granular cells using the peroxidase-anti-peroxidase method. The ultrastructural findings in both cases support a Schwann cell derivation of the granular cells. It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells.
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Bedetti, C.D., Martinez, A.J., Beckford, N.S. et al. Granular cell tumor arising in myelinated peripheral nerves. Vichows Archiv A Pathol Anat 402, 175–183 (1983). https://doi.org/10.1007/BF00695059
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DOI: https://doi.org/10.1007/BF00695059