Zusammenfassung
Die bei langzeitiger Sensibilisierung von Kaninchen mit homologem Lebergesamtextrakt beobachteten morphologischen Leberveränderungen (Infiltration der periportalen Felder, Aktivierung der Kupfferschen Sternzellen, Leberzellnekrosen) sind im wesentlichen auf die antigene Wirksamkeit der Cytoplasmafraktion zurückzuführen. Bei Sensibilisierung mit homologer Mikrosomen-Mitochondrienfraktion sind die Veränderungen wesentlich geringer ausgeprägt. Bei Behandlung mit homologer Leberparenchymzellkernfraktion konnten keine wesentlichen morphologischen Veränderungen nachgewiesen werden.
Summary
The morphologic changes in the liver (infiltrates in the periportal regions, hyperactivity of the von Kupffer cells, liver cell necroses) observed after prolonged sensitization of rabbits with extracts of homologous whole liver are due primarily to the antigenic effect of the cytoplasmic fractions. With the sensitization with homologous microsomal-mitochondrial fractions, the changes are essentially less extensive. With the injections of homologous fractions of nuclei of hepatic parenchymal cells no major changes can be demonstrated.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Behar, A. J., andC. Tal: Experimental liver necrosis produced by the injection of homologous whole liver with adjuvant. J. Path. Bact.77, 519 (1959).
D'amelio, V., andP. Perlmann: The distribution of soluble antigens in cellular structures of rat liver. Exp. Cell Ees.19, 383 (1960).
Ishii, K., andS. Yamamoto: Liver cirrhosis and autoallergy. In:G. A. Martini u.S. Sherlock, Aktuelle Probleme der Hepatologie. Stuttgart: Georg Thieme 1962.
Jahiel, R. I., andD. Koffler: Hepatic granulomas induced in guinea pigs by Freund adjuvant with and without homologous liver. Brit. J. exp. Path.42, 338 (1961).
Laufer, A., C. Tal, andA. J. Behar: Effect of adjuvant and its components on the organs of various animal species; a comparative study. Brit. J. exp. Path.40, 1 (1959).
Norkin, S. A., L. S. Gottlieb, andN. Zamchek: Effect of liver homogenate and Freund adjuvant on guinea pig liver and other organs. Amer. J. dig. Dis.7, 824 (1962).
Pollak, V. E., E. Mandema, andM. Garstenstein: Serum antinuclear factor in patients and relatives: observation in systemic lupus erythematosus and liver disease. J. clin. Invest.40, 1071 (1961).
Scheiffakth, F., H. Warnatz, H. Götz u.G. Kettner: Tierexperimentelle Studien über die Bildung humoraler Organautoantikörper gegen homo- und autologes Lebergewebe. Z. Gastroenterologie2, 279 (1964).
Schneider, W., andG. Hogeboom: Intracellular distribution of enzymes. V. Further studies on the distribution of cytochrome in rat liver homogenates. J. biol. Chem.183, 123 (1950).
Steiner, J. W., J. S. Carruthers, R. Baumal, andS. R. Kalifat: Experimental immunologic liver injury and the concept of autodestruction. Part I and II. Canad. med. Ass. J.85, 1369, 1425 (1961).
Vogt, P. K.: The immunology of liver microsomes. I. The properties of the quantitative precipitin system. II. Immunological relations of microsomes to other cell fractions. III. The localization of tissue specific antigens within the structural components of endoplastic reticulum. Z. Naturforsch.15 B, 213, 218, 221 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scheiffarth, F., Warnatz, H. & Niederer, W. Tierexperimentelle Untersuchungen zur Pathogenese der chronischen Hepatitis. Virchows Arch. path Anat. 339, 358–363 (1965). https://doi.org/10.1007/BF00959697
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00959697