Summary
Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved.
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Adal, M.N.: The fine structure of the sensory region of cat muscle spindles. J. Ultrastruct. Res.26, 332–353 (1969)
Adams, R.D.: Innervation and blood vessels of muscle. In: Disease of muscle. 3d ed., pp. 54–109. New York: Harper and Row 1975
Banker, B.Q., Girvin, J.P.: The ultrastructural features of the mammalian muscle spindle. J. Neuropathol. Exp. Neurol.30, 155–195 (1971)
Banker, B.Q., Girvin, J.P.: The ultrastructural features of the normal and de-efferented muscle spindle. J. Neuropathol. Exp. Neurol.30, 136 (1971)
Barker, D. (ed.): Symposium on muscle receptors. Hong Kong: Hong Kong Univ. Press 1962
Cazzato, G., Walton, J.N.: The pathology of the muscle spindle. Study of biopsy material in various muscular and neuromuscular diseases. J. Neurol. Sci.7, 15–70 (1968)
During, M., Andres, K.H.: Zur Feinstruktur der Muskelspindel von Mammalia. Anat. Anz.124, 566–573 (1969)
Haslock, D.I., Wright, V., Harriman, D.G.F.: Neuromuscular disorders in rheumatoid arthritis. tA motor-point muscle biopsy study. Quart. J. Med.39, 335–358 (1970)
Katz, B.: The terminals of the afferent nerve fibre in the muscle spindle of the frog. Phil. Trans. R. Soc. (London)243, 221 (1961) cit. Banker, B.Q. and Girvin, J.P.: The ultrastructural features of the mammalian muscle spindle.
Landon, D.N.: Electron microscopy of muscle spindles. In: Control and innervation of skeletal muscle, Andrew, B.L. (ed.). A symposium at Queen's College. Dundee, Scotland: D.C. Thomson 1966
Magyar, E., Talerman, A., Wouters, H.W.: Histological abnormalities in the muscle spindles in rheumatoid arthritis. Ann. Rheum. Dis.32, 143–150 (1973)
Magyar, E., Talerman, A., Mohacsy, J., Wouters, H.W., Bruijn, W.C. de: Muscle changes in rheumatoid arthritis. A review of the literature with a study of 100 cases. Virchows Arch. A Path. Anat. and Histol.373, 267–278 (1977)
Marrillees, N.C.R.: The fine structure of muscle spindles in lumbrical muscles of the rat. J. Biophys. Biochem. Cytol.7, 725–742 (1960)
Morrison, L.R., Short, C.L., Ludwig, A.O., Schwab, R.S.: The neuro-muscular system in rheumatoid arthritis. Am. J. Med. Sci.214, 33–49 (1947)
Moritz, U.: Studies on motor nerve conduction in rheumatoid arthritis. Acta Rheum. Scand.10, 99–108 (1964)
Ovalle, W.K.: Fine structure of the avian muscle spindle capsule. Cell Tiss. Res.166, 285–298 (1976)
Patel, A.N., Lalitha, V.S., Dastur, D.K.: The spindles in normal and pathological muscle. An assessment of the histological changes. Brain91, 747–750 (1968)
Ruffini, A.: On the minute anatomy of the neuro-muscular spindles of the cat, and their physiological significance. J. Physiol. (Lond.)23, 190–208 (1898)
Steinberg, V.L.: Neuropathy in rheumatoid arthritis. Brit. Med. J.1, 1600–1603 (1960)
Venable, J.H., Coggeshal, R.: A simplified lead citrate stain for use in electron microscopy. J. Cell Biol.25, 407–408 (1965)
Zelenà, J., Soukup, T.: Ultrastructural differentiation of muscle spindles after de-efferentation. Folia Morphol. (Praha)22, 268–269 (1974)
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Temporary Research Fellow the Rotterdam Centre for Rheumatic Disease
Present address: Division of Pathology, Department of Obstetrics and Gynaecology, University of Chicago, Chicago, Illinois 60637, USA
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Magyar, E., Talerman, A., de Bruijn, W.C. et al. Muscle spindles in rheumatoid arthritis. Virchows Arch. A Path. Anat. and Histol. 382, 191–200 (1979). https://doi.org/10.1007/BF01102874
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DOI: https://doi.org/10.1007/BF01102874