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Carcinoembryonic antigen like antigen in granular cell myoblastomas

An immunohistochemical study

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Summary

A series of granular cell myoblastomas (GCM) and other benign and malignant tumours of soft tissue were examined for cytoplasmic content of carcinoembryonic antigen (CEA) by the two-layer conjugated immunoperoxidase technique. Using a commercial rabbit anti-CEA serum only granular cell myoblastomas showed positive cytoplasmic reaction. Pretreatment with periodic acid made this reaction less intense, but when the commercial rabbit anti-CEA serum was absorbed with tissue powder from normal human spleen the positive reaction was totally abolished. It is concluded that the positivity of GCM for CEA using commercial rabbit anti-CEA serum is due to the content of non-specific cross-reacting antigen (NCA) and maybe other cross-reacting glycoproteins in this tumour, and not to CEA as claimed in a previous study.

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Authors and Affiliations

  1. Institute of Pathology, Aalborg Hospital, DK-9000, Aalborg, Denmark

    Karsten Nielsen, Stein Meling Paulsen & Preben Johansen

Authors
  1. Karsten Nielsen
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  2. Stein Meling Paulsen
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  3. Preben Johansen
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Nielsen, K., Paulsen, S.M. & Johansen, P. Carcinoembryonic antigen like antigen in granular cell myoblastomas. Vichows Archiv A Pathol Anat 401, 159–162 (1983). https://doi.org/10.1007/BF00692641

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  • DOI: https://doi.org/10.1007/BF00692641

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