Summary
Ultra-thin sections obtained from routine biopsy specimens and cytological smears of 3 cases, together with one autopsy case suggestive of herpes oesophagitis, clearly demonstrate herpes viruses. The infected epithelial cells reveal different stages of virus replication and propagation. Cowdry A type inclusion bodies, however, representing early alterations in the course of infection are less frequent. Ground-glass looking nuclei of light microscopical balloon cells and infected multinuclear giant cells of epithelial origin are characteristic changes of the late ulcerative stage of herpes oesophagitis usually seen at the time of detection. These typical virus induced cell changes are mostly to be found at the ulcers edge.
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References
Chambers TJ (1978) Multinucleate giant cells. J Pathol 126:125–148
Chou SM, Cherry JD (1967) Ultrastructure of Cowdry type A inclusions. I. In human herpes simplex encephalitis. Neurology 17:75–586
Feiden W, Borchard F, Bürrig KF, Pfitzer P (1984) Herpes oesophagitis. I. Light microscopical and immunohistochemical investigations. Virchows Archiv [Pathol Anat] 404:167–176
Ghadially FN (1982) Ultrastructural pathology of the cell and matrix. 2nd ed. Butterworth London, Boston, Sydney, Wellington, Durban, Toronto. p 104
Hübner G (1981) Möglichkeiten und Grenzen der Erkennung einer viralen Pathogenese in Diagnostik und Forschung. Eletronenmikroskopie (Referat). Verh Dtsch Ges Pathol 65:29–47
Itabashi HH, Bass DM, McCulloch JR (1966) Inclusion body of acute inclusion encephalitis. An electron-microscopic study in a case of suspected herpes simplex encephalitis. Arch Neurol 14:493–505
Leestma JE, Bornstein MB, Sheppard RD, Feldman LA (1969) Ultrastructural aspects of herpes simplex virus infection in organized cultures of mammalian nervous tissue. Lab Invest 20:70–78
McDowell EM (1978) Fixation and processing. In: Trump BF, Jones RT (eds.) Diagnostic electron microscopy, vol 1. John Wiley & Sons New York, Chichester, Brisbane, Toronto. pp 113–139
Mirra SS, Bryan JA, Butz WC, Miles ML (1982) Concomitant herpes-monilial esophagitis: case report with ultrastructural study. Hum Pathol 13:760–763
Morecki R, Becker NH (1968) Human herpesvirus infection. Its fine structure identification in paraffin-embedded tissue. Arch Pathol 86:292–296
Nash G, Foley FD (1970) Herpetic infection of the middle and lower respiratory tract. Am J Clin Pathol 54:857–863
Ng ABP, Reagan JW, Lindner E (1970) The cellular manifestations of primary and recurrent herpes genitalis. Acta Cytol 14:124–129
Nii S, Morgan C, Rose HM (1968) Electron microscopy of herpes simplex virus. II. Sequence of development. J Virol 2:517–536
Patrizi G, Middelkamp JN, Reed CA (1968) Fine structure of herpes simplex virus hepatoadrenal necrosis in the newborn. Am J Clin Pathol 49:325–341
Roy S, Wolman L (1969) Electron microscopic observation on the virus particles in herpes simplex encephalitis. J Clin Pathol 22:51–59
Schäfer R, Ormanns W, Pfeifer U (1981) Zur autoptischen Diagnostik von Herpes simplex Infektionen. Verb Dtsch Ges Pathol 65:230–234
Smith J, Coleman DV (1983) Electron microscopy of cells showing viral cytopathic effects in Papanicolaou smears. Acta Cytol 27:605–613
Strano AJ (1976) Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 11:53–75
Swanson JL, Craighead JE, Reynolds ES (1966) Electron microscopic observations on herpes-virus hominis (herpes simplex virus) encephalitis in man. Lab Invest 15:1966–1981
Viloria JE, Garcia JH (1976) Human herpes simplex encephalitis (cellular events). Beitr Pathol 157:14–22
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Bürrig, KF., Borchard, F., Feiden, W. et al. Herpes oesophagitis. Vichows Archiv A Pathol Anat 404, 177–185 (1984). https://doi.org/10.1007/BF00704062
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DOI: https://doi.org/10.1007/BF00704062