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Histopathological predictive factors in Ewing's sarcoma of bone and clinicopathological correlations

A retrospective study of 261 cases

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Summary

A retrospective multifactorial analysis on 261 previously untreated patients with Ewing's sarcoma (Es) of bone has been carried out in order to ascertain the prognostic value of several histological variables on survival. Among those cases accepted as Es, 208 (80% of the patients) were considered to be “typical Es”, while 40 (15%) displayed a large cell predominance, being subclassified as “atypical large cell Es”. Furthermore, 13 patients (5%) possessed tumours of endothelial-like appearance. Eleven cases which displayed a mixed histological configuration were finally included within one of the three previous groups according to their predominant histological pattern.

After adjustment for therapeutic regimens and initial location of the tumour, only two histological characteristics remain significant; i.e. the presence of necrosis (p=0.002) and, to a lesser degree, the presence of filagree “en damier” pattern (p=0.08), both of which are of poor prognostic value. From this study, it can be assumed that the morphological (and possibly histogenetical) heterogeneity of Es of bone has no prognostic influence on survival.

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References

  • Apel R, Delling G, Krumme H, Winkler K, Salzer-Kuntschik M (1985) Nuclear polymorphism in osteosarcoma as a prognostic factor for the effect of chemotherapy. A quantitative study. Virchows Arch (Pathol Anat) 405:215–223

    Google Scholar 

  • Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH (1979) Malignant small cell tumor of the thoracopulmonary region of childhood. A distinctive clinicopathologic entity of uncertain histogenesis. Cancer 43:2438–2451

    Google Scholar 

  • Breslow N (1979) Statistical methods for censored survival data. Environ Health Perspect 32:181–192

    Google Scholar 

  • Costa J, Wesley RA, Glatstein E, Rosenberg SA (1984) The grading of soft-tissue sarcomas: Results of a clinico-histopathological correlation in a series of 163 cases. Cancer 53:530–538

    Google Scholar 

  • Cox DR (1972) Regression model and life-tables. J R Stat Soc 33:187–220

    Google Scholar 

  • Deméocq F, Carton P, Patte C, Oberlin O, Sarrazin D, Lemerle J (1984a) Traitement du sarcome d'Ewing par chimiothérapie initiale intensive. Premier bilan d'un protocole multicentrique français. Presse Méd 13:717–721

    Google Scholar 

  • Deméocq F, Oberlin O, Brunat-Mentigny M, Carton P, Lacombe MJ, Olive D, Patte C, Sarrazin D, Tron P, Lemerle J (1984b) Primary chemotherapy and tumor resection in Ewing's sarcoma of the ribs. Report of the French Society of Paediatric Oncology. Eur Paediatr Haematol Oncol 1:245–250

    Google Scholar 

  • Dixon WJ, Brown MB, Engelman L, Franc JW, Hill MA, Jennrich RI, Toporek JD (1981) BMDP statistical software. University of California Press, Berkeley, California

    Google Scholar 

  • Glaubiger DL, Makuch R, Schwarz J, Levine As, Johnson RE (1980) Determination of prognostic factors and their influence on therapeutic results in patients with Ewing's sarcoma. Cancer 45:2213–2219

    Google Scholar 

  • Gonzales-Crussi F, Wolfson SL, Migusi K, Nakajima T (1984) Peripheral neuroectodermal tumors of the chest wall in childhood. Cancer 54:2519–2527

    Google Scholar 

  • Jaffe R, Santamaria M, Yunis EJ, Tannery NH, Agostini RM, Medina J, Goodman M (1984) The neuroectodermal tumor of bone. Am J Surg Pathol 8:885–898

    Google Scholar 

  • Johnson RE, Pomeroy TC (1975) Prognostic factors for survival in Ewing's sarcoma. Am J Roentgenol Radium Ther Nucl Med 123:583–587

    Google Scholar 

  • Kinsella TJ, Lichter AS, Miser GS, Gerber L, Glatstein E (1984) Local treatment of Ewing's sarcoma: Radiation therapy versus surgery. Cancer Treat Rep 68:695–702

    Google Scholar 

  • Kissane JM, Askin FB, Foulkes M, Stratton LB, Shirley SF (1983) Ewing's sarcoma of bone: Clinico-pathological aspects of 303 cases from the Intergroup Ewing's Sarcoma Study. Hum Pathol 14:773–779

    Google Scholar 

  • Llombart-Bosch A, Blaché R, Peydro-Olaya A (1978) Ultrastructural study of 28 cases of Ewing's sarcoma. Typical and atypical forms. Cancer 41:1362–1373

    Google Scholar 

  • Llombart-Bosch A, Peydro-Olaya A, Gomar F (1980) Ultrastructure of one Ewing's sarcoma of bone with endothelial character and a comparative review of the vessels in 27 cases of typical Ewing's sarcoma. Pathol Res Pract 167:71–87

    Google Scholar 

  • Llombart-Bosch A, Blaché R, Peydro-Olaya A (1982) Round cell sarcomas of bone and their differential diagnosis (with particular emphasis on Ewing's sarcoma and reticulosarcoma). A study of 233 tumours with optical and electron microscopical techniques. Pathol Ann 17 (pt 2):113–145

    Google Scholar 

  • Llombart-Bosch A (1983) Ewing's sarcoma of bone. A unique tumoral entity? Guest lecture. IXth European Congress of Pathology, Hamburg (19–23 Sept)

  • Martin SE, Dwyer A, Kissane JM, Costa J (1982) Small cell osteosarcoma. Cancer 50:990–996

    Google Scholar 

  • Mendenhall CM, Marcus RB, Enneking WF, Springfield DS, Thar TL, Millon R (1983) The prognostic significance of soft-tissue extension in Ewing's sarcoma. Cancer 51:913–917

    Google Scholar 

  • Miser J, Steis R, Longo DL, Belasco JB, Triche T, Kinsella TJ (1985) Treatment of newly diagnosed high-risk sarcomas and primitive neuroectodermal tumors (TNET) in children and young adults. Proc Am Soc Clin Oncol 4:240 (C-935)

    Google Scholar 

  • Nascimento AG, Uni KK, Pritchard DJ, Cooper KL, Dahlin DC (1980) A clinico-pathological study of 20 cases of large cell (atypical) Ewing's sarcoma of bone. Am J Surg Pathol 4:29–36

    Google Scholar 

  • Nesbit ME, Perez CA, Tefft M, Burgert EOI Vietti TJ, Kissane J, Pritchard DJ, Gehan EA (1981) Multimodal therapy for the management of primary non-metastatic Ewing's sarcoma of bone: An intergroup study. Natl Cancer Inst Monogr 56:255–262

    Google Scholar 

  • Oberlin O, Patte C, Deméocq F, Lacombe MJ, Brunat-Mentigny M, Demaille MC, Tron P, N'guyen Bui, Lemerle J (1985) The response to initial chemotherapy as a prognostic factor in localized Ewing's sarcoma. Eur J Cancer Clin Oncol 21:463–467

    Google Scholar 

  • Perez CA, Razek A, Tefft M, Nesbit ME, Burgert EO, Kissane J, Vietti T, Gehan EA (1977) Analysis of local tumor control in Ewing's sarcoma: Preliminary results of a Cooperative Intergroup Study. Cancer 40:2864–2873

    Google Scholar 

  • Pilepich MV, Vietti TG, Nesbit ME, Tefft M, Kissane J, Burgert EO, Pritchard D, Gehan EA (1981) Ewing's sarcoma of the vertebral column. Int J Radiat Oncol Biol Phys 7:27–31

    Google Scholar 

  • Pomeroy TC, Johnson RE (1975) Combined modality therapy of Ewing's sarcoma. Cancer 35:36–47

    Google Scholar 

  • Pritchard DJ, Dahlin DC, Dauphine RT, Taylor WF, Beabout JW (1975) Ewing's sarcoma: A clinico-pathological and statistical analysis of patients surviving five years or longer. J Bone Joint Surg (Ann) 57:10–16

    Google Scholar 

  • Rosen G, Caparros B, Mosende C, McCormick B, Huvos AG, Marcove R (1978) Curability of Ewing's sarcoma and considerations for future therapeutical trials. Cancer 41:888–889

    Google Scholar 

  • Rosen G, Caparros B, Niremberg A, Marcove RC, Huvos AG, Kosloff C, Lane JM, Murphy M (1981) Ewing's sarcoma; ten years' experience with adjuvant chemotherapy. Cancer 47:2204–2213

    Google Scholar 

  • Stefani E, Carzoglio M, Pellegrini HD, Olivera L, Cendan M, Kasdorf H (1984) Ewing's sarcoma: value of tumor necrosis as a predictive factor. Bull Cancer (Paris) 71:16–21

    Google Scholar 

  • Thomas PR, Foulkes MA, Gilula LA, Burgert EO, Evans RG, Kissane J, Nesbit ME, Pritchard DJ, Tefft M, Vietti TJ (1983) Primary Ewing's sarcoma of the ribs: A report from the Intergroup Ewing's Sarcoma Study. Cancer 51:1021–1027

    Google Scholar 

  • Triche TJ, Ross WJ (1978) Glycogen-containing neuroblastoma with clinical and histopathological features in Ewing's sarcoma. Cancer 41:1425–1432

    Google Scholar 

  • Triche TJ, Askin FB (1983) Neuroblastoma and the differential diagnosis of small round blue cell tumors. Hum Pathol 14:569–595

    Google Scholar 

  • Trojani M, Contesso G, Coindre JM, Rouëssé J, Bui NB, Demascarell A, Goussot JF, David F, Bonichon F, Lagarde C (1984) Soft-tissue sarcomas of adults: Study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 33:37–42

    Google Scholar 

  • Wartelle M, Kramar A, Jan P, Kruger D (1983) “PIGAS”: an interactive statistical database management system. In: Proceedings of the Second International Workshop on Statistical Database Management, Los Altos, California

  • Zucker JM, Henry-Amar M (1977) Therapeutic controlled trial in Ewing's sarcoma. Report on the results of a trial by the Clinical Cooperative Group on Radio- and Chemotherapy of the E.O.R.T.C. Eur J Cancer 13:1019–1023

    Google Scholar 

  • Zucker JM, Henry-Amar M, Sarrazin D, Blaché R, Patte C, Schweisguth O (1983) Intensive systemic chemotherapy in localized Ewing's sarcoma in childhood. A historical trial. Cancer 52:415–423

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Medical School of Valencia, Spain

    A. Llombart-Bosch

  2. Department of Pathology, Hospital St Vincent de Paul, F-7500, Paris, France

    G. Contesso & M. J. Lacombe

  3. Department of Medical Statistics, Hospital St Vincent de Paul, F-7500, Paris, France

    M. Henry-Amar

  4. Department of Paediatrics, Hospital St Vincent de Paul, F-7500, Paris, France

    O. Oberlin

  5. Department of Surgery, Hospital St Vincent de Paul, F-7500, Paris, France

    J. Dubousset

  6. Department of Medicine B, Institut Gustave Roussy, Villejuif, France

    J. Rouëssé

  7. Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France, France

    D. Sarrazin

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  1. A. Llombart-Bosch
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  2. G. Contesso
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  3. M. Henry-Amar
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  4. M. J. Lacombe
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  5. O. Oberlin
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  6. J. Dubousset
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  7. J. Rouëssé
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  8. D. Sarrazin
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Llombart-Bosch, A., Contesso, G., Henry-Amar, M. et al. Histopathological predictive factors in Ewing's sarcoma of bone and clinicopathological correlations. Vichows Archiv A Pathol Anat 409, 627–640 (1986). https://doi.org/10.1007/BF00713429

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  • DOI: https://doi.org/10.1007/BF00713429

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