Abstract
With the aim of detecting the timing of p53 and Ki-ras gene alterations in the gastric adenoma-carcinoma sequence, 19 early gastric adenocarcinomas arising from adenomas were studied. Immunohistochemically, 5 adenocarcinomas were positive for p53; 3 focally and 2 diffusely. The p53 point mutations were detected in a focal area with p53 immunoreactivity in 2 of the 5 p53-positive adenocarcinomas. This indicated that p53 point mutations may play a less crucial part in malignant conversion of adenoma to adenocarcinoma in the stomach than in the colon. No Ki-ras gene mutations at codons 12 and 13 were detected in any lesion. These results suggest that the adenoma-carcinoma sequence in the stomach has a different mechanism from that in the colon.
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Supported in part by a Grant-in-Aid from the Ministry of Health and Welfare of Japan
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Sakurai, S., Sano, T., Maeshima, A. et al. Gastric adenoma — carcinoma sequence with special reference to p53 and Ki-ras gene alterations. Vichows Archiv A Pathol Anat 427, 119–124 (1995). https://doi.org/10.1007/BF00196515
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DOI: https://doi.org/10.1007/BF00196515