Skip to main content
Log in

Effects of peripheral nerve lesions during pregnancy on parturition in rats

  • Original Articles
  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Summary

Bilateral section of either the sensory or motor branch of the pelvic nerve or pudendal nerve was performed in rats on days 8–10 of pregnancy, and the effects on delivery were observed. Bilateral resection of the sensory branch of the pelvic nerve reduced the number of live pups per litter, and increased the number of stillbirths and the number of fetuses retained in utero per litter at day 24. Sectioning motor components of the pelvic nerve, or both motor and sensory components of the pudendal nerve, had no effects on delivery in rats. We conclude that of the peripheral nerves evaluated in this study, only the sensory branch of the pelvic nerve is required for normal vaginal delivery in this species.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bradley WE, Sundin T (1982) The physiology and pharmacology of urinary tract disfunction. Clin Neuropharmacol 5:131–158

    Google Scholar 

  • Burden HW, Louis TM, Lawrence IE Jr (1980) Lack of effect of unilateral pelvic neurectomy on parturition and leuteolysis in the rat. IRCS Med Sci 8:166–167

    Google Scholar 

  • Carlson RR, DeFeo VJ (1965) Role of the pelvic nerve vs. the abdominal sympathetic nerves in the reproductive function of the female rat. Endocrinology 77:1014–1022

    Google Scholar 

  • Fitzgerald M (1983) Capsaicin and sensory neurons — a review. Pain 15:109–130

    Article  CAS  PubMed  Google Scholar 

  • Higuchi T, Uchide K, Honda K, Negoro H (1986) Oxytocin release during parturition in the pelvic-neurectomized rat. J Endocrinol 109:149–154

    Google Scholar 

  • Higuchi T, Uchide K, Honda K, Negoro H (1987) Pelvic neurectomy abolishes the fetus-expulsion reflex and induces dystocia in the rat. Exp Neurol 96:443–455

    Google Scholar 

  • Ljungdahl A, Hokfelt T, Nilsson G (1978) Distribution of substance P-like immunoreactivity in the central nervous system of the rat. I. Cell bodies and nerve terminals. Neuroscience 3:861–943

    Article  CAS  PubMed  Google Scholar 

  • Louis TM, Lawrence IE Jr, Becker RF, Burden HW (1978) Prostaglandin F2α, prostaglandin E2, progesterone, 20α dihydroprogesterone and ovarian 20α hydroxysteroid dehydrogenease activity in preparturient pelvic neurectomized rats. Proc Soc Exp Biol Med 158:631–636

    Google Scholar 

  • Maggi CA, Santicoioli P, Borsini F, Giuliani S, Meli A (1986) The role of the capsaicin-sensitive innervation of the rat urinary bladder in the activation of micturition reflex. Naunyn-Schmiedeberg's Arch Pharmakol 332:276–283

    Google Scholar 

  • Maggi CA, Santicoioli F, Meli A (1987) Evidence for the involvement of a capsaicin-innervation in the afferent branch of micturition reflex in rats. Acta Physiol Acad Sci Hung 69:425–435

    Google Scholar 

  • Morgan C, Nadelhaft I, DeGroat WC (1981) The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus. J Comp Neurol 201:415–440

    Google Scholar 

  • McKenna KE. Nadelhaft I (1986) The organization of the pudendal nerve in the male and female rat. J Comp Neurol 248:532–549

    Google Scholar 

  • Nadelhaft I, Roppolo J, Morgan C, DeGroat WC (1983) Parasympathetic preganglionic neurons and visceral primary afferents in monkey sacral spinal cord revealed following application of horseradish peroxidase to pelvic nerve. J Comp Neurol 216:36–52

    Google Scholar 

  • Nadelhaft I, Booth AM (1984) The location and morphology of preganglionic neurons in the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J Comp Neurol 226:238–245

    Google Scholar 

  • Nunez R, Gross GH, Sachs BD (1986) Origin and central projections of rat dorsal penile nerve: possible direct projection to autonomic and somatic neurons by primary afferents of nonmuscle origin. J Comp Neurol 247:417–429

    Google Scholar 

  • Pacheco P, Martinez-Gomez M, Whipple B, Beyer C, Komisaruk DR (1989) Somato-motor components of the pelvic and pudendal nerves of the female rat. Brain Res 490:85–94

    Google Scholar 

  • Spies HG, Forbes YM, Clegg MT (1971) The influence of coitus, suckling and prolactin injections on pregnancy in pelvic neurectomized rats. Proc Soc Exp Biol Med 138:470–474

    Google Scholar 

  • Ueyama T, Arakawa H, Mizuno N (1987) Central distribution of efferent and afferent components of the pudendal nerve in rat. Anat Embryol 177:37–49

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Burden, H.W., Price, G.T., Renegar, R.H. et al. Effects of peripheral nerve lesions during pregnancy on parturition in rats. Anat Embryol 182, 499–501 (1990). https://doi.org/10.1007/BF00178916

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00178916

Key words

Navigation